利用参与制霉菌素生产的克隆基因来发现新的多烯类产生菌链霉菌菌株。
Use of a cloned gene involved in candicidin production to discover new polyene producer Streptomyces strains.
作者信息
Gil J A, Criado L M, Alegre T, Martín J F
机构信息
Area de Microbiologia, Facultad de Biología, Universidad de León, Spain.
出版信息
FEMS Microbiol Lett. 1990 Jun 15;58(1):15-8. doi: 10.1016/0378-1097(90)90094-7.
PMID:2397878
Abstract
A p-aminobenzoic synthase gene (pabS) from Streptomyces griseus IMRU 3570 involved in candicidin production was used as probe to find new aromatic polyene producing Streptomyces strains. The pab gene hybridizes with 6 out of 16 Streptomyces strains, and those strains which hybridize turned out to be polyene producers. Such strains were never before described as polyene producers.
摘要
来自参与杀假丝菌素生产的灰色链霉菌IMRU 3570的对氨基苯甲酸合酶基因（pabS）被用作探针，以寻找新的产生芳香多烯的链霉菌菌株。pab基因与16株链霉菌中的6株杂交，而那些杂交的菌株被证明是多烯生产者。这类菌株以前从未被描述为多烯生产者。
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