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与肉用型本地鸡感染禽白血病病毒J亚群（ALV-J）相关的多中心组织细胞增生症

Multicentric histiocytosis related to avian leukosis virus subgroup J (ALV-J)-infection in meat-type local chickens.

作者信息

Furukawa Seiko, Tsukamoto Kenji, Maeda Minoru

机构信息

Fukushima Meat Hygiene Inspection Office, 38-6 Kitasawada, Senouemachi, Fukushima-shi, Fukushima 960-0101, Japan.

出版信息

J Vet Med Sci. 2014 Jan;76(1):89-92. doi: 10.1292/jvms.13-0263. Epub 2013 Aug 23.

DOI:10.1292/jvms.13-0263
PMID:23978900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3979936/
Abstract

Gross lesions characterized by swollen livers and spleens accompanied by diffuse white miliary spots, which resembled those of Marek's disease, were detected in two flocks of local meat-type chickens at a Japanese poultry processing plant in June and August 2010. The microscopic examinations revealed proliferative foci consisting of spindle or polymorphic cells in the interstitium of livers, splenic follicles and the interstitium of kidneys. These cells were positive immunohistochemically with Iba1 antibody, indicating they were histiocytic cells. Some of them contained antigens of avian leukosis virus (ALV) by immunohistochemistry,and the env gene of ALV subgroup J was detected from the spleens by polymerase chain reaction (PCR). Phylogenetic analysis of the PCR product indicated that the env gene might be descended from the American ADOL-7501 strain of ALV-J. These results suggest that the swollen livers and spleens of the meat-type chickens may come from histiocytic proliferation caused by ALV-J infection.

摘要

2010年6月和8月，在日本一家家禽加工厂的两群本地肉用型鸡中，发现了以肝脏和脾脏肿大并伴有弥漫性白色粟粒状斑点为特征的肉眼病变，这些病变与马立克氏病的病变相似。显微镜检查显示，在肝脏间质、脾滤泡和肾脏间质中存在由梭形或多形性细胞组成的增殖灶。这些细胞经免疫组化检测，与Iba1抗体呈阳性反应，表明它们是组织细胞。其中一些细胞经免疫组化检测含有禽白血病病毒（ALV）抗原，通过聚合酶链反应（PCR）从脾脏中检测到了J亚群ALV的env基因。对PCR产物的系统发育分析表明，env基因可能源自美国ADOL-7501株ALV-J。这些结果表明，肉用型鸡的肝脏和脾脏肿大可能是由ALV-J感染引起的组织细胞增殖所致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ca/3979936/49505ace6c0c/jvms-76-089-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ca/3979936/c27f1c5fb052/jvms-76-089-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ca/3979936/49a21bc40cd5/jvms-76-089-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ca/3979936/971e0b4d3ca8/jvms-76-089-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ca/3979936/5401ff82afff/jvms-76-089-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ca/3979936/49505ace6c0c/jvms-76-089-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ca/3979936/c27f1c5fb052/jvms-76-089-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ca/3979936/49a21bc40cd5/jvms-76-089-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ca/3979936/971e0b4d3ca8/jvms-76-089-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ca/3979936/5401ff82afff/jvms-76-089-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50ca/3979936/49505ace6c0c/jvms-76-089-g005.jpg

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Tumors associated with avian leukosis virus subgroup J in layer hens during 2007 to 2009 in China.2007年至2009年期间中国蛋鸡中与J亚群禽白血病病毒相关的肿瘤
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Subgroup J avian leukosis virus-induced histiocytic sarcomatosis occurs only in persistently viremic but not immunotolerized meat-type chickens.
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