Division of Physical Biology, Department of Materials and Energy Sciences & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
Analyst. 2013 Nov 7;138(21):6511-6. doi: 10.1039/c3an01267k.
Using synchrotron radiation X-ray fluorescence (SRXRF), we have examined the biodistribution and pulmonary toxicity of nanoscale titanium dioxide (nanoTiO2) in mice at the elemental level. Notably, nanoTiO2 particles were mainly retained in lungs after intratracheal instillation, slowly cleared and were still present at 3 months. Different methods of intratracheal instillation influenced the clearance of nanoTiO2 from lungs. NanoTiO2 interfered with the natural distribution of K, Ca, Fe, Cu and Zn in lungs. We have thus demonstrated that SRXRF provides an effective approach to investigate the distribution of metal nanomaterials and native metal elements in tissues and organs, which offers new opportunities for revealing nanotoxic mechanisms of nanomaterials.
利用同步辐射 X 射线荧光（SRXRF），我们在元素水平上研究了纳米二氧化钛（nanoTiO2）在小鼠体内的分布和肺部毒性。值得注意的是，气管内滴注后纳米 TiO2 颗粒主要滞留在肺部，缓慢清除，在 3 个月时仍有存在。气管内滴注的不同方法影响了 nanoTiO2 从肺部的清除。nanoTiO2 干扰了 K、Ca、Fe、Cu 和 Zn 在肺部的自然分布。因此，我们证明了 SRXRF 为研究金属纳米材料和天然金属元素在组织和器官中的分布提供了一种有效的方法，为揭示纳米材料的纳米毒性机制提供了新的机会。
