Kataoka Hiroharu, Miyoshi Takekazu, Neki Reiko, Yoshimatsu Jun, Ishibashi-Ueda Hatsue, Iihara Koji
Department of Neurosurgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Neurol Med Chir (Tokyo). 2013;53(8):549-54. doi: 10.2176/nmc.53.549.
Subarachnoid hemorrhage (SAH) due to the rupture of an intracranial aneurysm (IA) is a rare but serious complication of pregnancy and is responsible for important morbidity and mortality during pregnancy. This study reviewed reports of ruptured IA during pregnancy and the puerperium, and our own cases of ruptured IA in pregnant women. Hemorrhage occurred predominantly during the third trimester of pregnancy, when maternal cardiac output and blood volume increase and reach maximum. Physiological and hormonal changes in pregnancy are likely to affect the risk of IA rupture. Ruptured IAs during pregnancy should be managed based on neurosurgical considerations, and the obstetrical management of women with ruptured IAs should be decided according to the severity of SAH and the gestational age. Emergent cesarean section followed by clipping or coiling of aneurysms is indicated if the maternal condition and the gestational age allow such interventions. Although SAH during pregnancy can result in disastrous outcomes, the necessity of intracranial screening for high-risk pregnant women is still controversial.
颅内动脉瘤(IA)破裂导致的蛛网膜下腔出血(SAH)是妊娠罕见但严重的并发症,是妊娠期间重要的发病和死亡原因。本研究回顾了妊娠和产褥期IA破裂的报告以及我们自己诊治的孕妇IA破裂病例。出血主要发生在妊娠晚期,此时孕妇的心输出量和血容量增加并达到最大值。妊娠期间的生理和激素变化可能会影响IA破裂的风险。妊娠期间破裂的IA应基于神经外科考虑进行处理,IA破裂女性的产科处理应根据SAH的严重程度和孕周来决定。如果母体状况和孕周允许进行此类干预,则应紧急剖宫产,随后夹闭或栓塞动脉瘤。尽管妊娠期间的SAH可能导致灾难性后果,但对高危孕妇进行颅内筛查的必要性仍存在争议。