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严重急性放射综合征：中国一名受60Co源致死剂量照射的事故受害者接受HLA配型不合外周血干细胞移植和间充质干细胞治疗

Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells.

作者信息

Guo Mei, Dong Zheng, Qiao Jianhui, Yu Changlin, Sun Qiyun, Hu Kaixun, Liu Guangxian, Wei Li, Yao Bo, Man Qiuhong, Sun Xuedong, Liu Zhiqing, Song Zhiwu, Yu Chengze, Chen Ying, Luo Qingliang, Liu Sugang, Ai Hui-Sheng

机构信息

Department of Hematology and Transplantation, Affiliated Hospital of the Academy of Military Medical Sciences, 8 Dongdajie, Beijing 100071, China.

出版信息

J Radiat Res. 2014 Mar 1;55(2):205-9. doi: 10.1093/jrr/rrt102. Epub 2013 Aug 26.

DOI:10.1093/jrr/rrt102
PMID:23979075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3951066/
Abstract

This is a case report of a 32-year-old man exposed to a total body dose of 14.5 Gy γ-radiation in a lethal (60)Co-source irradiation accident in 2008 in China. Frequent nausea, vomiting and marked neutropenia and lymphopenia were observed from 30 min to 45 h after exposure. HLA-mismatched peripheral blood stem cell transplantation combined with infusion of mesenchymal stem cells was used at Day 7. Rapid hematopoietic recovery, stable donor engraftment and healing of radioactive skin ulceration were achieved during Days 18-36. The patient finally developed intestinal obstruction and died of multi-organ failure on Day 62, although intestinal obstruction was successfully released by emergency bowel resection.

摘要

这是一例关于一名32岁男性的病例报告，该男子于2008年在中国一起致死性的（60）钴源辐射事故中全身受到了14.5戈瑞的γ辐射。在暴露后30分钟至45小时期间观察到频繁的恶心、呕吐以及显著的中性粒细胞减少和淋巴细胞减少。在第7天采用了人类白细胞抗原不相合的外周血干细胞移植并联合间充质干细胞输注。在第18至36天期间实现了快速的造血恢复、供体稳定植入以及放射性皮肤溃疡愈合。尽管通过急诊肠切除成功解除了肠梗阻，但患者最终在第62天出现肠梗阻并死于多器官功能衰竭。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d869/3951066/2c32fbca087c/rrt10202.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d869/3951066/65608c882ff0/rrt10201.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d869/3951066/2c32fbca087c/rrt10202.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d869/3951066/65608c882ff0/rrt10201.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d869/3951066/2c32fbca087c/rrt10202.jpg

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Int J Radiat Biol. 2010 Sep;86(9):800-8. doi: 10.3109/09553002.2010.481320.
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Radiation accidents over the last 60 years.
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The Particle Radiobiology of Multipotent Mesenchymal Stromal Cells: A Key to Mitigating Radiation-Induced Tissue Toxicities in Cancer Treatment and Beyond?多能间充质基质细胞的粒子放射生物学：减轻癌症治疗及其他领域辐射诱导组织毒性的关键？
Front Oncol. 2021 Apr 12;11:616831. doi: 10.3389/fonc.2021.616831. eCollection 2021.
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