耐药表皮葡萄球菌中携带 fusB 和毒力基因的噬菌体相关岛的新结构。
New structure of phage-related islands carrying fusB and a virulence gene in fusidic acid-resistant Staphylococcus epidermidis.
机构信息
Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.
出版信息
Antimicrob Agents Chemother. 2013 Nov;57(11):5737-9. doi: 10.1128/AAC.01433-13. Epub 2013 Aug 26.
Abstract
Nucleotide sequencing of the fusB-flanking regions in two fusidic acid-resistant Staphylococcus epidermidis isolates with the type IV aj1-leader peptide (LP)-fusB structure (lacking aj1) revealed that their fusB gene was located on novel phage-related islands inserted downstream of smpB and are here referred to as SeRIfusB-3692 and SePIfusB-857. The novel SePIfusB-857 structure was followed by SeCI857, forming a composite pathogenicity island which contained a putative virulence gene, vapE. The linkage of fusB and vapE may contribute to bacterial adaption.
摘要
对两个带有 IV 型 aj1 前导肽（LP）-fusB 结构（缺失 aj1）的耐夫西地酸表皮葡萄球菌分离株的 fusB 侧翼区域进行核苷酸测序表明，它们的 fusB 基因位于 smpB 下游插入的新型噬菌体相关岛屿上，现称为 SeRIfusB-3692 和 SePIfusB-857。新型 SePIfusB-857 结构后面跟着 SeCI857，形成一个包含推定毒力基因 vapE 的复合致病性岛。fusB 和 vapE 的连接可能有助于细菌适应。
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