多药耐药肺炎克雷伯菌替加环素耐药性产生的巢式病例对照研究。
Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae.
机构信息
Department of Medicine.
出版信息
Antimicrob Agents Chemother. 2013 Nov;57(11):5743-6. doi: 10.1128/AAC.00827-13. Epub 2013 Aug 26.
Abstract
We performed a nested case-control study (ratio of 1:4) on the emergence of tigecycline-resistant multidrug-resistant Klebsiella pneumoniae (TR-MDRKP) isolates among patients who initially presented with a tigecycline-susceptible MDRKP isolate. Out of 260 patients, 24 (9%) had a subsequent clinical culture positive for a TR-MDRKP isolate within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted odds ratio [OR], 5.06; 95% confidence interval [CI], 1.80 to 14.23; P = 0.002) was the only independent predictor of subsequent isolation of a TR strain.
摘要
我们对最初表现为替加环素敏感的多药耐药肺炎克雷伯菌（MDRKP）分离株的患者中出现替加环素耐药的多药耐药肺炎克雷伯菌（TR-MDRKP）分离株的情况进行了巢式病例对照研究（1:4 的比例）。在 260 名患者中，有 24 名（9%）在 90 天随访期间随后的临床培养呈 TR-MDRKP 分离株阳性。在逻辑回归分析中，替加环素的使用（调整后的优势比 [OR]，5.06；95%置信区间 [CI]，1.80 至 14.23；P = 0.002）是随后分离出 TR 株的唯一独立预测因子。
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Diagn Microbiol Infect Dis. 2013 Jun;76(2):217-21. doi: 10.1016/j.diagmicrobio.2013.02.009. Epub 2013 Mar 19.
2
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J Infect. 2012 Dec;65(6):584-6. doi: 10.1016/j.jinf.2012.09.007. Epub 2012 Sep 19.
3
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5
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6
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