超氧阴离子介导的大肠杆菌对抗菌药物的保护作用。
Superoxide-mediated protection of Escherichia coli from antimicrobials.
机构信息
Public Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
出版信息
Antimicrob Agents Chemother. 2013 Nov;57(11):5755-9. doi: 10.1128/AAC.00754-13. Epub 2013 Aug 26.
Abstract
Antimicrobial lethality is promoted by reactive oxygen species (ROS), such as superoxide, peroxide, and hydroxyl radical. Pretreatment with subinhibitory concentrations of plumbagin or paraquat, metabolic generators of superoxide, paradoxically reduced killing for oxolinic acid, kanamycin, and ampicillin. These pretreatments also reduced an oxolinic acid-mediated ROS surge. Defects in SoxS MarA or AcrB eliminated plumbagin- and paraquat-mediated MIC increases but maintained protection from killing. Thus, superoxide has both protective and detrimental roles in response to antimicrobial stress.
摘要
活性氧（ROS）如超氧化物、过氧化物和羟自由基可促进抗菌药物的杀伤作用。用亚抑菌浓度的白花丹素或百草枯预处理，可生成超氧化物，这反而会降低金霉素、卡那霉素和氨苄青霉素的杀菌作用。这些预处理还降低了金霉素介导的 ROS 激增。SoxS MarA 或 AcrB 的缺陷消除了白花丹素和百草枯介导的 MIC 增加，但仍能提供对抗杀菌作用的保护。因此，超氧化物在对抗抗菌应激时具有保护和有害的双重作用。
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