抑制活性氧积累可延缓和/或降低几种抗葡萄球菌药物的致死率。
Inhibitors of reactive oxygen species accumulation delay and/or reduce the lethality of several antistaphylococcal agents.
机构信息
Department of Biochemistry, Harbin Medical University, Harbin, Heilongjiang Province, China.
出版信息
Antimicrob Agents Chemother. 2012 Nov;56(11):6048-50. doi: 10.1128/AAC.00754-12. Epub 2012 Sep 4.
Abstract
Perturbation of hydroxyl radical accumulation by subinhibitory concentrations of 2,2'-bipyridyl plus thiourea protects Escherichia coli from being killed by 3 lethal antimicrobial classes. Here, we show that 2,2'-bipyridyl plus thiourea delays and/or reduces antimicrobial killing of Staphylococcus aureus by daptomycin, moxifloxacin, and oxacillin. While the protective effect of 2,2'-bipyridyl plus thiourea varied among strains and compounds, the data support the hypothesis that hydroxyl radical enhances antimicrobial lethality.
摘要
亚抑菌浓度的 2,2'-联吡啶加硫脲通过扰乱羟自由基积累来保护大肠杆菌免受 3 种致死性抗菌药物的杀伤。在这里，我们发现 2,2'-联吡啶加硫脲可延迟和/或降低达托霉素、莫西沙星和苯唑西林对金黄色葡萄球菌的杀菌作用。虽然 2,2'-联吡啶加硫脲的保护作用因菌株和化合物而异，但这些数据支持了羟自由基增强抗菌药物致死性的假设。
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