Comerford K B, Buchan W, Karakas S E
Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The University of California at Davis Medical Center, Sacramento, CA, USA.
Family and Consumer Sciences Department, California State University Sacramento, Sacramento, CA, USA.
Horm Metab Res. 2014 Mar;46(3):224-31. doi: 10.1055/s-0033-1353204. Epub 2013 Aug 26.
Fat accumulation is associated with the release of many novel adipokines such as retinol-binding protein 4 and fatty acid-binding protein 4. These adipokines have been linked to insulin resistance, metabolic syndrome, type 2 diabetes and cardiovascular disease. Since weight loss is the first step for the treatment of metabolic syndrome, which increases the risks for both type 2 diabetes and cardiovascular disease, we have investigated the effects of weight loss on serum retinol-binding protein 4 and fatty acid-binding protein 4 in obese individuals with this syndrome. Twenty-nine obese female subjects with metabolic syndrome, aged 18-62 years completed a 2-month weight loss diet plan. Data were collected from dual-energy X-ray absorptiometry and indirect calorimetry. Blood was taken at baseline and at 2 months and assayed for adipokines, lipids, and insulin resistance parameters. The change in circulating fatty acid-binding protein 4 levels were inversely correlated with total weight loss (p<0.02) and lean mass loss (p<0.01), but not with fat mass loss. Retinol-binding protein 4 levels did not track with any measure of body composition. Changes in leptin levels were found to correlate with weight loss (p<0.02), fat loss (p<0.03), and lean mass loss (p<0.05). Fatty acid-binding protein 4 levels increased and retinol-binding protein 4 levels did not change during moderate weight loss in obese women with metabolic syndrome; however, several other risk factors for type 2 diabetes and cardiovascular disease did improve with weight loss.
脂肪堆积与许多新型脂肪因子的释放有关，如视黄醇结合蛋白4和脂肪酸结合蛋白4。这些脂肪因子与胰岛素抵抗、代谢综合征、2型糖尿病和心血管疾病有关。由于体重减轻是治疗代谢综合征的第一步，而代谢综合征会增加2型糖尿病和心血管疾病的风险，因此我们研究了体重减轻对患有该综合征的肥胖个体血清视黄醇结合蛋白4和脂肪酸结合蛋白4的影响。29名年龄在18至62岁之间患有代谢综合征的肥胖女性受试者完成了一项为期2个月的减肥饮食计划。数据通过双能X线吸收法和间接测热法收集。在基线和2个月时采集血液，检测脂肪因子、脂质和胰岛素抵抗参数。循环中脂肪酸结合蛋白4水平的变化与总体重减轻（p<0.02）和瘦体重减轻（p<0.01）呈负相关，但与脂肪量减少无关。视黄醇结合蛋白4水平与任何身体成分指标均无关联。发现瘦素水平的变化与体重减轻（p<0.02）、脂肪减少（p<0.03）和瘦体重减轻（p<0.05）相关。在患有代谢综合征的肥胖女性适度体重减轻期间，脂肪酸结合蛋白4水平升高，视黄醇结合蛋白4水平未发生变化；然而，随着体重减轻，2型糖尿病和心血管疾病的其他一些危险因素确实有所改善。
