Reinehr Thomas, Stoffel-Wagner Birgit, Roth Christian L
Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, 45711, Datteln, Germany.
Metabolism. 2007 Dec;56(12):1735-41. doi: 10.1016/j.metabol.2007.07.019.
Adipocyte fatty acid-binding protein (A-FABP) has been reported to be increased in obese adults and to be related to metabolic syndrome. Because studies concerning A-FABP in weight loss are limited and studies in obese children are missing, we analyzed A-FABP in obese children before and after weight loss. Fasting serum A-FABP, leptin, insulin, glucose, triglycerides, low-and high-density lipoprotein cholesterol, high-sensitivity C-reactive protein, and tumor necrosis factor alpha concentrations as markers of the metabolic syndrome, and weight status (body mass index and percentage body fat based on skinfold measurements) were determined in 30 obese children (median age, 11.9 years) before and after participating in a 1-year obesity intervention. Furthermore, A-FABP levels were measured in 10 nonobese children of similar age, sex, and pubertal stage. Obese children had significantly (P < .001) higher A-FABP concentrations compared with nonobese children. In backward multivariate linear regression analysis, A-FABP correlated significantly (P < .05) with percentage body fat and leptin, but not with any of the markers of the metabolic syndrome. Changes of A-FABP concentrations correlated significantly with changes of percentage body fat (r = 0.53, P = .001) and leptin (r = 0.55, P < .001), but not with any changes of parameters of the metabolic syndrome. Substantial weight loss in 10 children led to a significant (P < .05) decrease in A-FABP levels in contrast to the 20 children without change of weight status. In cross-sectional as well as longitudinal analyses, A-FABP levels were related to weight status and leptin levels. Further longitudinal studies are necessary to study the relationship between A-FABP concentrations and parameters of the metabolic syndrome.
据报道，脂肪细胞脂肪酸结合蛋白（A-FABP）在肥胖成年人中含量增加，且与代谢综合征有关。由于关于减肥过程中A-FABP的研究有限，且缺乏对肥胖儿童的研究，我们分析了肥胖儿童减肥前后的A-FABP情况。在30名肥胖儿童（中位年龄11.9岁）参与为期1年的肥胖干预前后，测定了空腹血清A-FABP、瘦素、胰岛素、葡萄糖、甘油三酯、低密度和高密度脂蛋白胆固醇、高敏C反应蛋白以及肿瘤坏死因子α浓度作为代谢综合征的标志物，同时还测定了体重状况（基于皮褶测量的体重指数和体脂百分比）。此外，还测量了10名年龄、性别和青春期阶段相似的非肥胖儿童的A-FABP水平。与非肥胖儿童相比，肥胖儿童的A-FABP浓度显著更高（P < .001）。在向后多变量线性回归分析中，A-FABP与体脂百分比和瘦素显著相关（P < .05），但与任何代谢综合征标志物均无相关性。A-FABP浓度的变化与体脂百分比变化（r = 0.53，P = .001）和瘦素变化（r = 0.55，P < .001）显著相关，但与代谢综合征参数的任何变化均无相关性。与20名体重状况未改变的儿童相比，10名儿童体重显著减轻导致A-FABP水平显著降低（P < .05）。在横断面和纵向分析中，A-FABP水平均与体重状况和瘦素水平有关。需要进一步进行纵向研究以探讨A-FABP浓度与代谢综合征参数之间的关系。
