Department of Pharmaceutics & Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu, China.
Planta Med. 2013 Oct;79(15):1447-52. doi: 10.1055/s-0033-1350768. Epub 2013 Aug 26.
A chemical investigation of the EtOAc-soluble fraction from the ethanol extract of the medullae of Juncus effusus led to the isolation of three new 9,10-dihydrophenanthrenes, juncuenins E-G (1-3); two new phenanthrenes, dehydrojuncuenins D-E (4-5); one new feruloylated glycoside (6); and one known 9,10-dihydrophenanthrene (7). The structures of these compounds were determined by analyzing their spectroscopic data. Metabolites 1-4 and 7 were further evaluated for their in vitro cytotoxic activities against seven human cancer lines (A549, MCF-7, BEL-7402, HeLa, COLO205, BGC-823, and SK-OV-3). Among them, compound 1 exhibited weak cytotoxicity against MCF-7 and HeLa cell lines. Compound 7 showed moderate cytotoxicity against MCF-7 and HeLa cell lines, with IC50 values of 9.17 and 19.6 µM, respectively.
从灯心草髓的乙醇提取物的 EtOAc 可溶部分进行化学研究，分离得到三种新的 9,10-二氢菲，即 juncuenins E-G（1-3）；两种新的菲，去氢 juncuenins D-E（4-5）；一种新的阿魏酰化糖苷（6）；和一种已知的 9,10-二氢菲（7）。这些化合物的结构通过分析其光谱数据确定。代谢物 1-4 和 7 进一步评估了它们对七种人癌细胞系（A549、MCF-7、BEL-7402、HeLa、COLO205、BGC-823 和 SK-OV-3）的体外细胞毒性活性。其中，化合物 1 对 MCF-7 和 HeLa 细胞系表现出微弱的细胞毒性。化合物 7 对 MCF-7 和 HeLa 细胞系表现出中等细胞毒性，IC50 值分别为 9.17 和 19.6µM。
