Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
Fitoterapia. 2013 Sep;89:224-30. doi: 10.1016/j.fitote.2013.06.008. Epub 2013 Jun 15.
Phytochemical investigation of the n-BuOH extract of the rhizomes of Anemone taipaiensis led to the isolation of three new oleanane-type triterpenoid saponins (1-3), together with four known saponins (4-7). Their structures were elucidated on the basis of spectroscopic analysis and chemical derivatization. All the compounds were isolated for the first time from A. taipaiensis. The cytotoxicity of these compounds was evaluated in five human cancer cell lines including A549 (lung carcinoma), HeLa (cervical carcinoma), HepG2 (hepatocellular carcinoma), HL-60 (promyelocytic leukemia), and U87MG (glioblastoma). The monodesmosidic saponin 4 exhibited cytotoxic activity toward all cancer cell lines, with IC50 values ranging from 6.42 to 18.16 μM. In addition, the bisdesmosidic saponins 1 and 7 showed selective cytotoxicity against the U87MG cells.
从白头翁的根茎的 n-BuOH 提取物中进行植物化学研究，分离得到了三种新的齐墩果烷型三萜皂苷（1-3），以及四种已知的皂苷（4-7）。基于光谱分析和化学衍生化，确定了它们的结构。所有化合物均首次从白头翁中分离得到。评估了这些化合物在五种人癌细胞系（包括 A549（肺癌）、HeLa（宫颈癌）、HepG2（肝癌）、HL-60（早幼粒细胞白血病）和 U87MG（神经胶质瘤））中的细胞毒性。单糖苷皂苷 4 对所有癌细胞系均表现出细胞毒性，IC50 值范围为 6.42-18.16 μM。此外，双糖苷皂苷 1 和 7 对 U87MG 细胞具有选择性细胞毒性。
