在灯心草髓部发现的两种新型抗焦虑菲类化合物。
Two new anxiolytic phenanthrenes found in the medullae of Juncus effusus.
作者信息
Wang Yang, Li Gui-Yun, Fu Qian, Hao Tai-Sen, Huang Jian-Mei, Zhai Hai-Feng
出版信息
Nat Prod Commun. 2014 Aug;9(8):1177-8.
PMID:25233602
Abstract
Six phenanthrenes, 2-methoxy-7-hydroxy-1-methyl-5-vinyl phenanthrene (1), juncusin (2), dehydroeffusol (3), juncusol (4), effusol (5), and dehydroeffusal (6), were isolated from the medullae of Juncus effusus L. Compounds 1 and 2 were identified as being new structures, and both of them showed anxiolytic activity at dosages of 10 and 2.5 mg/kg, respectively.
摘要
从灯心草的髓部中分离出六种菲类化合物，分别为2-甲氧基-7-羟基-1-甲基-5-乙烯基菲（1）、灯心草辛（2）、去氢灯心草酚（3）、灯心草酚（4）、灯心草醇（5）和去氢灯心草醛（6）。化合物1和2被鉴定为新结构，它们在剂量分别为10 mg/kg和2.5 mg/kg时均表现出抗焦虑活性。
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