Tanimoto Hiroki, Kakiuchi Kiyomi
Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan.
Nat Prod Commun. 2013 Jul;8(7):1021-34.
Organic azides have been exploited since their discovery because of their high reactivities. Various organic reactions using azides have been synthetically applied in chemical biology, pharmaceuticals, medicinal, and agricultural areas. In this review, we present some recent applications and developments of organic azides in the total synthesis of natural products (mostly within five years), especially alkaloids. We focus not only on application examples of organic azides, but also show their preparation methods including recently reported procedures concerning their decomposing and reducing methods in the syntheses of bioactive molecules.
自从有机叠氮化物被发现以来，因其高反应活性而得到了广泛应用。使用叠氮化物的各种有机反应已被合成应用于化学生物学、制药、医学和农业领域。在本综述中，我们介绍了有机叠氮化物在天然产物全合成（主要是近五年内）中的一些最新应用和进展，特别是生物碱方面。我们不仅关注有机叠氮化物的应用实例，还展示了它们的制备方法，包括最近报道的在生物活性分子合成中有关其分解和还原方法的程序。
