Pd(II)催化共轭 1,3-二烯的分子内 1,2-氨基烷基化反应合成吡咯里嗪。
Pd(II)-catalyzed intramolecular 1,2-aminoalkylation of conjugated 1,3-dienes for the synthesis of pyrrolizidines.
机构信息
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
出版信息
Org Lett. 2013 Sep 6;15(17):4370-3. doi: 10.1021/ol401901h. Epub 2013 Aug 27.
PMID:23980544
Abstract
A palladium(II)-catalyzed tandem cyclization reaction involving an intramolecular 1,2-aminoalkylation of N-4,6-dienyl β-keto amides has been developed. This process provides an efficient method for the rapid assembly of pyrrolizidines starting from linear substrates in moderate to good yields and high to excellent diastereoselectivities.
摘要
钯（II）催化的串联环化反应涉及 N-4,6-二烯基β-酮酰胺的分子内 1,2-氨基烷基化，该过程为从线性底物出发，以中等至良好的收率和高至优异的非对映选择性快速构建吡咯里西啶提供了一种有效方法。
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