Palmiere Cristian, Mangin Patrice, Werner Dominique
University Centre of Legal Medicine, Rue du Bugnon 21, 1011, Lausanne, Switzerland.
J Forensic Sci. 2014 Jan;59(1):161-6. doi: 10.1111/1556-4029.12265. Epub 2013 Aug 23.
The concentrations of 3-beta-hydroxybutyrate (3HB) in femoral blood, urine, vitreous humor as well as pericardial and cerebrospinal fluids were retrospectively examined in a series of medico-legal autopsies, which included cases of diabetic ketoacidosis, hypothermia fatalities without ethanol in blood, bodies presenting mild decompositional changes, and sudden deaths in chronic alcoholics. Similar increases in 3HB concentrations were observed in blood, vitreous, and pericardial fluid, irrespective of the cause of death, suggesting that pericardial fluid and vitreous can both be used as alternatives to blood for postmortem 3HB determination. Urine 3HB levels were higher than blood values in most cases. Cerebrospinal fluid 3HB levels were generally lower than concentrations in blood and proved to be diagnostic of underlying metabolic disturbances only when significant increases occurred.
在一系列法医学尸检中，对股动脉血、尿液、玻璃体液以及心包液和脑脊液中的3-β-羟基丁酸（3HB）浓度进行了回顾性检测，这些尸检包括糖尿病酮症酸中毒病例、血液中无乙醇的低温死亡病例、呈现轻度腐败变化的尸体以及慢性酒精中毒者的猝死病例。无论死因如何，在血液、玻璃体液和心包液中均观察到3HB浓度有类似升高，这表明心包液和玻璃体液均可作为死后测定3HB的替代血液样本。在大多数情况下，尿液中的3HB水平高于血液中的值。脑脊液中的3HB水平通常低于血液中的浓度，只有在显著升高时才被证明可诊断潜在的代谢紊乱。
