Felby Søren, Nielsen Erik, Thomsen Jørgen L
Institute of Forensic Medicine, University of Southern Denmark, Winsløwparken 17, 5000, Odense C, Denmark.
Forensic Sci Med Pathol. 2008;4(2):100-7. doi: 10.1007/s12024-007-9018-4. Epub 2007 Nov 27.
The distribution of the ketone bodies: acetone, acetoacetate, and D-beta-hydroxybutyrate, between blood, vitreous humor, spinal fluid, and urine was examined in 105 medico-legal autopsies. The ketone body concentration in the body fluids was determinated by head-space gas chromatography. The correlation between blood and the body fluids could be described with regression lines on the logarithmic-transformed results. The correlation is dependent on the ketone body concentration. The ketone bodies in spinal fluid show the best correlation to blood, followed by vitreous humor, and last urine. The concentration dependence in spinal fluid is mainly due to ketone bodies being metabolized in the brain. The human brain utilizes ketone bodies during normal nutritional state. In vitreous humor, the dependence is mainly due to protein bindings of acetoacetate and beta-hydroxybutyrate in blood and the difference in dry matter between blood and vitreous humor.
在105例法医尸检中，研究了酮体（丙酮、乙酰乙酸和D-β-羟基丁酸）在血液、玻璃体液、脑脊液和尿液之间的分布情况。通过顶空气相色谱法测定体液中的酮体浓度。对对数转换后的结果用回归线描述血液与其他体液之间的相关性。这种相关性取决于酮体浓度。脑脊液中的酮体与血液的相关性最佳，其次是玻璃体液，最后是尿液。脑脊液中浓度的依赖性主要是由于酮体在大脑中被代谢。在正常营养状态下，人类大脑会利用酮体。在玻璃体液中，这种依赖性主要是由于血液中乙酰乙酸和β-羟基丁酸的蛋白质结合以及血液与玻璃体液干物质的差异。
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