Garfin S R, Cohen M S, Massie J B, Abitbol J J, Swenson M R, Myers R R, Rydevik B L
Division of Orthopaedics and Rehabilitation, University of California, San Diego.
J Bone Joint Surg Am. 1990 Sep;72(8):1185-92.
The influence of hypotension on the function of nerve-roots of the cauda equina under acute graded compression was studied with use of an established porcine model. In twenty adult miniature pigs, the nerve-roots of the cauda equina were compressed at pressures of zero (sham), fifty, 100, or 200 millimeters of mercury, and hypotension was induced with sodium nitroprusside. Compression was maintained for two hours, and a ninety-minute period of recovery followed. The nerve-roots were monitored electrophysiologically throughout the experiment. To assess the effect of compression and hypotension on the function of the nerve-roots, values of afferent and efferent amplitude and nerve-conduction velocity were compared with values in twenty adult miniature pigs that had similar graded compression without hypotension. Hypotension significantly affected efferent and afferent amplitudes at the end of the compression period; the effect remained significant at the end of the recovery period. The most profound effect of hypotension occurred during compression at fifty millimeters of mercury--a pressure that had no effect on the function of the nerves in normotensive animals.
利用已建立的猪模型，研究了急性分级压迫下低血压对马尾神经根功能的影响。在20只成年小型猪中，以零（假手术）、50、100或200毫米汞柱的压力压迫马尾神经根，并用硝普钠诱导低血压。压迫持续两小时，随后是90分钟的恢复时间。在整个实验过程中对神经根进行电生理监测。为了评估压迫和低血压对神经根功能的影响，将传入和传出振幅以及神经传导速度的值与20只成年小型猪（这些猪有类似的分级压迫但无低血压）的值进行比较。低血压在压迫期结束时显著影响传出和传入振幅；在恢复期结束时，这种影响仍然显著。低血压最显著的影响发生在50毫米汞柱压迫期间——这个压力对血压正常动物的神经功能没有影响。
