Pedowitz R A, Garfin S R, Massie J B, Hargens A R, Swenson M R, Myers R R, Rydevik B L
Department of Orthopaedics and Rehabilitation, University of California, San Diego.
Spine (Phila Pa 1976). 1992 Feb;17(2):194-9. doi: 10.1097/00007632-199202000-00013.
Spinal nerve root compression occurs commonly in conditions such as herniated nucleus pulposus, spinal stenosis, and trauma. However, the pathophysiology of the symptoms and signs related to spinal nerve root compression is poorly understood. The purpose of the present study was to assess and compare effects of various pressures and durations of acute compression on spinal nerve root conduction in the pig cauda equina. Efferent conduction (compound motor action potentials) and afferent conduction (compound nerve action potentials) were monitored during compression for 2 or 4 hours with compression pressures of 0 (sham), 50, 100, or 200 mm Hg. Recovery from compression was monitored for 1.5 hours. No significant deficits in spinal nerve root conduction were observed with 0 or 50 mm Hg compression, compared to significant conduction deficits induced by 100 and 200 mm Hg compression. Three-way analysis of variance demonstrated significant effects of compression pressure and duration on conduction at the end of compression and recovery, with a significant difference between efferent and afferent conduction at the end of the recovery period. These observations suggest an interaction between biomechanical and microvascular mechanisms in the production of nerve root conduction deficits. Such information may relate to the motor and sensory dysfunction in clinical conditions associated with spinal nerve root compression.
脊髓神经根受压常见于诸如髓核突出、椎管狭窄和外伤等情况。然而，与脊髓神经根受压相关的症状和体征的病理生理学仍知之甚少。本研究的目的是评估和比较急性压迫的不同压力和持续时间对猪马尾神经脊髓神经根传导的影响。在压迫期间，用0（假手术）、50、100或200毫米汞柱的压迫压力监测传出传导（复合运动动作电位）和传入传导（复合神经动作电位）2或4小时。监测压迫后1.5小时的恢复情况。与100和200毫米汞柱压迫引起的明显传导缺陷相比，0或50毫米汞柱压迫未观察到脊髓神经根传导的明显缺陷。三因素方差分析表明，压迫压力和持续时间对压迫结束时和恢复时的传导有显著影响，恢复期结束时传出传导和传入传导之间存在显著差异。这些观察结果表明，在产生神经根传导缺陷方面，生物力学和微血管机制之间存在相互作用。这些信息可能与脊髓神经根受压相关临床情况中的运动和感觉功能障碍有关。
