Barrett Sara Jean
Alternative Solutions for Health, Bloomington, MN, USA.
Altern Ther Health Med. 2013;19 Suppl 1:26-30.
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) play an important role in both primary and secondary prevention of cardiovascular diseases (CVDs). Clinicians should strongly consider therapy with ω-3 PUFAs for individuals at risk for CVD and with known CVD, particularly individuals who are at increased risk for sudden cardiac death. The amount of ω-3 PUFA in erythrocyte membranes, which is the ω-3 index, could prove to be a modifiable risk factor for CVD. This review outlines potential mechanisms of action, the ω-3 index, results of clinical and prevention trials, and recommendations for ω-3 PUFA therapy in CVD. The majority of epidemiologic and controlled interventional studies have demonstrated that marine- and plant-derived ω-3 PUFAs have beneficial effects on CVD. The ω-3 index may prove to be a valuable tool for assessing an individual's need for increased ω-3 PUFAs through diet or supplementation.
ω-3多不饱和脂肪酸（ω-3 PUFAs）在心血管疾病（CVDs）的一级预防和二级预防中均发挥着重要作用。临床医生应强烈考虑对有CVD风险的个体以及已知患有CVD的个体，尤其是有心脏性猝死风险增加的个体，采用ω-3 PUFAs进行治疗。红细胞膜中ω-3多不饱和脂肪酸的含量，即ω-3指数，可能被证明是CVD的一个可改变的风险因素。本综述概述了ω-3 PUFAs的潜在作用机制、ω-3指数、临床和预防试验结果以及CVD中ω-3 PUFAs治疗的建议。大多数流行病学和对照干预研究表明，海洋来源和植物来源的ω-3 PUFAs对CVD有有益作用。ω-3指数可能被证明是评估个体通过饮食或补充剂增加ω-3 PUFAs需求的一个有价值的工具。
