谷胱甘肽硫转移酶T1/谷胱甘肽硫转移酶M1缺失与杀虫剂相关，且与帕金森病有关。
Nullity of GSTT1/GSTM1 related to pesticides is associated with Parkinson's disease.
作者信息
Pinhel Marcela Augusta de Souza, Sado Caroline Leiko, Longo Gabriela Dos Santos, Gregório Michele Lima, Amorim Gisele Sousa, Florim Greiciane Maria da Silva, Mazeti Camila Montoro, Martins Denise Poltronieri, Oliveira Fábio de Nazaré, Nakazone Marcelo Arruda, Tognola Waldir Antonio, Souza Dorotéia Rossi Silva
机构信息
FAMERP, São José do Rio Preto SP, Brasil.
出版信息
Arq Neuropsiquiatr. 2013 Aug;71(8):527-32. doi: 10.1590/0004-282X20130076.
Genetic and environmental factors affect the pathogenesis of Parkinson's disease (PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be related to the disease. This study aimed to evaluate the influence of genetic variants of GST (GSTT1/GSTM1) and their association with the exposure to environmental toxins in PD patients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variants were analyzed by polymerase chain reaction. We applied the Fisher's exact test and the χ2 test for statistical analysis (p<0.05). The present and absence for GSTT1 and GSTM1 were similar in patients and controls. The null for GSTT1 and GSTM1 (0/0) and exposure to pesticides prevailed in patients (18%) compared to controls (13%, p=0.014). This study suggests the association between PD and previous exposure to pesticides, whose effect may be enhanced in combination with null for GSTT1/GSTM1.
遗传和环境因素影响帕金森病（PD）的发病机制。谷胱甘肽S-转移酶（GST）的基因变异可能与该疾病有关。本研究旨在评估GST（GSTT1/GSTM1）基因变异的影响及其与PD患者环境毒素暴露的关联。我们研究了254例PD患者和169例对照。通过聚合酶链反应分析GSTM1/GSTT1变异。我们应用Fisher精确检验和χ2检验进行统计分析（p<0.05）。GSTT1和GSTM1的存在与否在患者和对照中相似。与对照（13%，p=0.014）相比，患者中GSTT1和GSTM1缺失（0/0）且接触农药的情况更为普遍（18%）。本研究表明PD与既往农药暴露之间存在关联，GSTT1/GSTM1缺失可能会增强其影响。
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