Ishitobi Yoshinobu, Nakayama Shinya, Kanehisa Masayuki, Higuma Haruka, Maruyama Yoshihiro, Okamoto Shizuko, Inoue Ayako, Imanaga Junko, Tanaka Yoshihiro, Tsuru Jusen, Hanada Hiroaki, Akiyoshi Jotaro
Department of Neuropsychiatry, Faculty of Medicine, Oita University, Oita, Japan.
Psychiatr Genet. 2013 Dec;23(6):255-7. doi: 10.1097/YPG.0000000000000002.
Previous studies have reported that the hypothalamic-pituitary-adrenal axis is involved with personality traits. We examined the association between corticotropin-releasing hormone receptor (CRHR) genes and personality traits. We investigated the 12 single-nucleotide polymorphisms of intron CRHR (six in CRHR1 and six in CRHR2, respectively) in 218 healthy volunteers using TaqMan PCR assays. Personality traits were assessed using the Revised NEO-Personality Inventory, the Temperament and Character Inventory, and the State-Trait Anxiety Inventory. No significant associations were observed between CRHR1 and CRHR2 expression and personality traits. These results fail to provide support for an association of CRHR1 and CRHR2 with personality traits in a Japanese adult population.
以往研究报道下丘脑-垂体-肾上腺轴与人格特质有关。我们研究了促肾上腺皮质激素释放激素受体（CRHR）基因与人格特质之间的关联。我们使用TaqMan PCR分析方法，对218名健康志愿者的CRHR内含子的12个单核苷酸多态性（分别在CRHR1中有6个，在CRHR2中有6个）进行了研究。使用修订版的大五人格量表、气质与性格量表以及状态-特质焦虑量表对人格特质进行评估。未观察到CRHR1和CRHR2的表达与人格特质之间存在显著关联。这些结果未能支持在日本成年人群体中CRHR1和CRHR2与人格特质存在关联的观点。
