Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, 200030, People's Republic of China.
J Mol Neurosci. 2020 Feb;70(2):145-154. doi: 10.1007/s12031-019-01396-8. Epub 2019 Aug 26.
There is evidence that corticotropin-releasing hormone receptor 1 (CRHR1) gene polymorphisms and indifferent impulsive personality traits play an important role in violent aggression in male adolescents. Genotyping for two tag single-nucleotide polymorphisms (SNP) (rs242924, rs17689966) was conducted using TaqMan SNP for 138 violent young male criminals, 98 nonviolent young male criminals, and 153 noncriminal adults. The general situation and personality traits (SSP) questionnaire was given to the young violent and nonviolent male criminal groups. The results showed that the frequency of the G allele in rs242924 of the CRHR1 gene in the violent aggression group was higher than that in the normal adult controls (P < 0.025, OR = 2.29, 95% CI = 1.13-4.62). The difference in genotype distribution was significant among the three groups (P < 0.05), and when the violent group was compared with the two control groups, no significant difference was found (P > 0.025). The impulsiveness, trait irritability, verbal trait aggression, and physical trait aggression scores in the violent group were significantly higher than those in the nonviolent group of adolescents. These findings suggest that the variance in CRHR1 gene polymorphisms and personality traits may play a role in violent aggression in male adolescents, and that the interaction of the CRHR1 gene and the impulsive personality trait may cause an increased susceptibility to violence towards others.
有证据表明，促肾上腺皮质激素释放激素受体 1（CRHR1）基因多态性和不同的冲动人格特质在男性青少年的暴力攻击中起着重要作用。使用 TaqMan SNP 对 138 名暴力年轻男性罪犯、98 名非暴力年轻男性罪犯和 153 名非犯罪成年人进行了两个标签单核苷酸多态性（SNP）（rs242924、rs17689966）的基因分型。一般情况和人格特质（SSP）问卷被给予年轻的暴力和非暴力男性罪犯群体。结果表明，CRHR1 基因 rs242924 中的 G 等位基因在暴力攻击组中的频率高于正常成年对照组（P < 0.025，OR = 2.29，95%CI = 1.13-4.62）。三组之间的基因型分布差异显著（P < 0.05），当将暴力组与两组对照组进行比较时，差异无统计学意义（P > 0.025）。暴力组的冲动性、特质易怒性、言语特质攻击性和身体特质攻击性得分明显高于非暴力组青少年。这些发现表明，CRHR1 基因多态性和人格特质的差异可能在男性青少年的暴力攻击中起作用，而 CRHR1 基因和冲动人格特质的相互作用可能导致对他人暴力的易感性增加。
