Ding Gang, Xu Weiguo, Hua Hongwei, Huang Qian, Liang Hongxiang, Ni Yufeng, Ding Zhaoheng
Department of Oncology, Chongming Branch of Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 202150, China.
Tumour Biol. 2013 Oct;34(5):2521-7. doi: 10.1007/s13277-013-0705-3. Epub 2013 Aug 28.
A few case-control studies were performed to assess the association between X-ray repair cross-complementing group 3 (XRCC3) rs861539 C/T polymorphism and lung cancer susceptibility, but no consistent finding was reported. In the present study, we performed a meta-analysis of 14 case-control studies with a total of 7,869 lung cancer cases and 10,778 controls to provide a comprehensive assessment of the association between XRCC3 rs861539 C/T polymorphism and lung cancer risk. Pooled odds ratios (ORs) and corresponding 95 % confidence intervals (95 % CIs) were calculated to assess the strength of the association. Overall, there was no significant association between XRCC3 rs861539 C/T polymorphism and lung cancer risk under all genetic models [OR (95 % CI) for T versus C, 1.00 (0.89-1.13), P = 0.99; OR (95 % CI) for TT versus CC, 1.07 (0.81-1.41), P = 0.62; OR (95 % CI) for TT/CT versus CC, 0.95 (0.84-1.07), P = 0.39; OR (95 % CI) for TT versus CT/CC, 1.10 (0.86-1.39), P = 0.62]. In the subgroup analyses of both Asians and Caucasians, there was still no significant association between XRCC3 rs861539 C/T polymorphism and lung cancer risk under all genetic models (All P values were more than 0.05). However, there was an obvious association between XRCC3 rs861539 C/T polymorphism and decreased risk of lung cancer in the subgroup analysis of the mixed population (All P values were less than 0.05). In addition, there was some risk of publication bias in the meta-analysis, and there was obvious discrepancy in the findings between studies with large sample size and studies with small sample size in the meta-analysis. The meta-analysis indicates that the association between XRCC3 rs861539 C/T polymorphism and lung cancer risk is still uncertain owing to the obvious discrepancy in the findings between studies with large sample size and studies with small sample size. More studies with large sample size are needed to further assess the association.
开展了一些病例对照研究，以评估X射线修复交叉互补基因3（XRCC3）rs861539 C/T多态性与肺癌易感性之间的关联，但未报告一致的研究结果。在本研究中，我们对14项病例对照研究进行了荟萃分析，这些研究总共纳入了7869例肺癌病例和10778例对照，以全面评估XRCC3 rs861539 C/T多态性与肺癌风险之间的关联。计算合并比值比（OR）和相应的95%置信区间（95%CI），以评估关联强度。总体而言，在所有遗传模型下，XRCC3 rs861539 C/T多态性与肺癌风险之间均无显著关联[T（突变型）对C（野生型）的OR（95%CI）为1.00（0.89 - 1.13），P = 0.99；TT对CC的OR（95%CI）为1.07（0.81 - 1.41），P = 0.62；TT/CT对CC的OR（95%CI）为0.95（0.84 - 1.07），P = 0.39；TT对CT/CC的OR（95%CI）为1.10（0.86 - 1.39），P = 0.62]。在亚洲人和高加索人的亚组分析中，在所有遗传模型下，XRCC3 rs861539 C/T多态性与肺癌风险之间仍无显著关联（所有P值均大于0.05）。然而，在混合人群的亚组分析中，XRCC3 rs861539 C/T多态性与肺癌风险降低之间存在明显关联（所有P值均小于0.05）。此外，荟萃分析存在一定的发表偏倚风险，且荟萃分析中样本量较大的研究与样本量较小的研究结果存在明显差异。该荟萃分析表明，由于样本量较大的研究与样本量较小的研究结果存在明显差异，XRCC3 rs861539 C/T多态性与肺癌风险之间的关联仍不确定。需要更多大样本量的研究来进一步评估这种关联。
