Xiao Xu-Yang, Wang Xiao-Dong, Zang Dong-Yu
Department of Thoracic Surgery, the First Affiliated Hospital of Liaoning Medical College, No 2, section 5 Renmin Street, Jinzhou, 121001 Liaoning Province, China.
Tumour Biol. 2012 Dec;33(6):2385-92. doi: 10.1007/s13277-012-0502-4. Epub 2012 Sep 11.
Matrix metalloproteinase-1 (MMP-1) plays an important role in the breakdown of extracellular matrix and mediates pathways of apoptosis, angiogenesis, and immunity. It has been demonstrated that MMP-1 overexpression is associated with tumor initiation, invasion, and metastasis. Many studies have investigated the association between MMP1-1607 1G/2G polymorphism and lung cancer risk, but the impact of MMP1-1607 1G/2G polymorphism on lung cancer is unclear owing to the obvious inconsistence among those studies. This study aimed to quantify the strength of the association between MMP1-1607 1G/2G polymorphism and lung cancer risk. We searched the PubMed, Embase, and Wanfang databases for studies on the association between MMP1-1607 1G/2G polymorphism and risk of lung cancer. We estimated summary odds ratio (OR) with its corresponding 95 % confidence interval (95%CI) to assess the association. Overall, MMP1-1607 1G/2G polymorphism was associated with increased risk of lung cancer under four genetic models (OR(2G versus 1G) = 1.21, 95 %CI 1.06-1.37; OR(2G2G versus 1G1G) = 1.36, 95%CI 1.09-1.70; OR(2G2G versus 2G1G+1G1G) = 1.33, 95 %CI 1.10-1.61; and OR(2G2G+2G1G versus 1G1G) = 1.15, 95 %CI 1.04-1.27). Meta-analyses of studies with high quality showed that MMP1-1607 1G/2G polymorphism was still associated with lung cancer risk under those four genetic models. Subgroup analyses by ethnicity and sensitivity analyses further identified the significant association in East Asians. No evidence of publication bias was observed. Meta-analyses of available data show a significant association between MMP1-1607 1G/2G polymorphism and lung cancer risk.
基质金属蛋白酶-1（MMP-1）在细胞外基质的分解中起重要作用，并介导细胞凋亡、血管生成和免疫途径。已有研究表明，MMP-1的过表达与肿瘤的发生、侵袭和转移有关。许多研究调查了MMP1-1607 1G/2G多态性与肺癌风险之间的关联，但由于这些研究结果明显不一致，MMP1-1607 1G/2G多态性对肺癌的影响尚不清楚。本研究旨在量化MMP1-1607 1G/2G多态性与肺癌风险之间关联的强度。我们检索了PubMed、Embase和万方数据库，以查找关于MMP1-1607 1G/2G多态性与肺癌风险关联的研究。我们估计了汇总比值比（OR）及其相应的95%置信区间（95%CI），以评估这种关联。总体而言，在四种遗传模型下，MMP1-1607 1G/2G多态性与肺癌风险增加相关（OR（2G对1G）=1.21，95%CI 1.06-1.37；OR（2G2G对1G1G）=1.36，95%CI 1.09-1.70；OR（2G2G对2G1G + 1G1G）=1.33，95%CI 1.10-1.61；OR（2G2G + 2G1G对1G1G）=1.15，95%CI 1.04-1.27）。高质量研究的荟萃分析表明，在这四种遗传模型下，MMP1-1607 1G/2G多态性仍与肺癌风险相关。按种族进行的亚组分析和敏感性分析进一步确定了东亚人群中的显著关联。未观察到发表偏倚的证据。对现有数据的荟萃分析表明，MMP1-1607 1G/2G多态性与肺癌风险之间存在显著关联。
