A comparison of the binding of angiotensin II to human placenta between normal and severe pre-eclamptic pregnancy.

We compared the binding of angiotensin II (A-II) to human placenta between normal and severe pre-eclamptic pregnancy. Our data did not show any statistically significant difference between normal and pre-eclamptic pregnancy in both the equilibrium dissociation constant (Kd) and the total number of placental A-II receptors. Therefore, changes in the binding of A-II to placenta might not be involved in the possible cause of activation of the renin-angiotensin system in the feto-placental unit in severe preeclampsia.