Kulkarni Atul P, Awode Rishikesh M
Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Mumbai, Maharashtra, India.
Indian J Anaesth. 2013 May;57(3):270-5. doi: 10.4103/0019-5049.115619.
Infectious complications of invasive procedures affect patient outcomes adversely. Choice of antiseptic solution at the time of insertion is one of the major factors affecting their incidence.
This study was undertaken to compare efficacy of chlorhexidine 2% and povidone iodine 10% for skin disinfection prior to placement of epidural and central venous catheters (CVCs).
A prospective randomised trial in the operating rooms of a tertiary referral cancer centre.
Sixty consecutive adult patients undergoing elective oncosurgery requiring placement of epidural and CVCs were enrolled. Paired skin swabs were collected before and after application of the antiseptic solution. The samples were incubated in McConkey's media and blood agar at 35°C for up to 24 h. Any bacterial growth was graded as: <10 colonies - poor growth, 10-50 colonies - moderate growth and >50 colonies as heavy growth. Data on demographics and antibiotic prophylaxis and costs was collected for all patients.
Student's t-test and Mann-Whitney tests were used to analyse data, P<0.05 was considered significant.
Demographics and antibiotic prophylaxis use was similar in both groups. Before application of antiseptic solution, a variety of micro-organisms were grown from most patients with growth ranging from none-heavy. No organism was grown after application of either antiseptic solution from any patient.
We found no differences between 2% chlorhexidine and 10% povidone-iodine for skin disinfection in regard to costs, efficacy or side-effects.
侵入性操作的感染并发症会对患者预后产生不利影响。插入操作时抗菌溶液的选择是影响其发生率的主要因素之一。
本研究旨在比较2%氯己定和10%聚维酮碘在硬膜外导管和中心静脉导管（CVC）置入术前用于皮肤消毒的效果。
在一家三级转诊癌症中心的手术室进行的一项前瞻性随机试验。
连续纳入60例接受择期肿瘤手术且需要置入硬膜外导管和CVC的成年患者。在应用抗菌溶液前后采集配对的皮肤拭子。样本在麦康凯培养基和血琼脂中于35°C孵育长达24小时。任何细菌生长分级为：<10个菌落 - 生长不良，10 - 50个菌落 - 中度生长，>50个菌落为重度生长。收集所有患者的人口统计学数据、抗生素预防使用情况及费用。
采用学生t检验和曼 - 惠特尼检验分析数据，P<0.05被认为具有统计学意义。
两组的人口统计学数据和抗生素预防使用情况相似。在应用抗菌溶液前，大多数患者培养出多种微生物，生长范围从无到重度。应用任何一种抗菌溶液后，任何患者均未培养出微生物。
我们发现2%氯己定和10%聚维酮碘在皮肤消毒的成本、效果或副作用方面没有差异。
