Department of Chemistry, Faculty of Engineering and Technology, Mody Institute of Technology and Science, Lakshmangarh, Sikar, Rajasthan 332311, India.
Bioinorg Chem Appl. 2013;2013:425832. doi: 10.1155/2013/425832. Epub 2013 Jul 28.
The present work stems from our interest in the synthesis, characterization, and antibacterial evaluation of organosilicon(IV) complexes of a class of amino-acid-based Schiff base which have been prepared by the interaction of ethoxytrimethylsilane with the Schiff bases (N OH) in 1 : 1 molar ratio. These complexes have been characterized by elemental analysis, molar conductance, and spectroscopic studies including electronic IR and NMR ((1)H, (13)C, and (29)Si) spectroscopy. The analytical and spectral data suggest trigonal bipyramidal geometry around the silicon atom in the resulting complexes. The ligands and their organosilicon complexes have also been evaluated for in vitro antimicrobial activity against bacteria (Bacillus cereus, Nocardia spp., E. aerogenes, Escherichia coli, Klebsiella spp., and Staphylococcus spp.). The complexes were found to be more potent as compared to the ligands.
本工作源于我们对一类基于氨基酸的席夫碱的有机硅(IV)配合物的合成、表征和抗菌评价的兴趣，这些配合物是通过乙氧基三甲基硅烷与席夫碱（N-OH）以 1:1 摩尔比相互作用制备的。这些配合物通过元素分析、摩尔电导率和光谱研究（包括电子 IR 和 NMR ((1)H、(13)C 和 (29)Si)光谱）进行了表征。分析和光谱数据表明，在所得配合物中，硅原子周围具有三角双锥几何形状。配体及其有机硅配合物也已针对细菌（蜡状芽孢杆菌、诺卡氏菌属、产气肠杆菌、大肠杆菌、克雷伯氏菌属和葡萄球菌属）进行了体外抗菌活性评估。与配体相比，这些配合物的活性更强。
