Naghshvar Farshad, Torabizadeh Zhila, Moslemi Zadeh Narges, Mirbaha Hooman, Gheshlaghi Parand
Department of Pathology, Mazandaran University of Medical Sciences, Sari, Iran.
ISRN Obstet Gynecol. 2013 Jul 31;2013:925062. doi: 10.1155/2013/925062. eCollection 2013.
Introduction. Preeclampsia (PE) is an important cause of mortality and morbidity for mothers, fetuses, and the newborns. Placenta plays a pivotal role in pathogenesis of PE. Hepatic growth factor (HGF) is a cytokine expressed by the mesenchymal stalk of placental villi during pregnancy and assumes a paracrine role in trophoblasts which express its receptor (c-MET). In the present study, we investigate the diagnostic value of s-Met (the soluble form of the receptor) in the first and second trimesters of pregnancy for early diagnosis of preeclampsia. Method and Materials. This is a case-control study conducted on 95 pregnant women. The serum level of s-Met was measured in the first and second trimesters, and the participants were followed until delivery. 44 individuals with preeclampsia (the case group) and 51 individuals without preeclampsia (the control group) were evaluated. Results. Serum level of s-Met in preeclamptic participants was lower than that of the control group in both the first and the second trimesters (P < 0.0001). In addition, serum levels of s-Met were significantly lower during the first and second trimesters in patients with early, severe preeclampsia compared to those with late, mild preeclampsia (P < 0.0001). The sensitivity and specificity of s-Met in the first and second trimesters were, respectively, (83%, 94%) and (77%, 94%) for early preeclampsia and (88%, 92%) and (86%, 98%) for severe preeclampsia. Conclusion. Considering our findings, serum level of s-Met may be used as a predictive factor for early detection of preeclampsia. Further research is required to corroborate the functional and therapeutic value of s-Met in preeclampsia.
引言。子痫前期（PE）是导致母亲、胎儿及新生儿发病和死亡的重要原因。胎盘在子痫前期的发病机制中起关键作用。肝细胞生长因子（HGF）是一种在孕期由胎盘绒毛间充质干表达的细胞因子，对表达其受体（c-MET）的滋养层细胞起旁分泌作用。在本研究中，我们探讨可溶性受体（s-Met）在妊娠早期和中期对子痫前期早期诊断的价值。方法与材料。这是一项针对95名孕妇的病例对照研究。在妊娠早期和中期测量s-Met的血清水平，并对参与者进行随访直至分娩。对44名单纯子痫前期患者（病例组）和51名无子痫前期患者（对照组）进行评估。结果。子痫前期患者在妊娠早期和中期的s-Met血清水平均低于对照组（P < 0.0001）。此外，与晚期轻度子痫前期患者相比，早期重度子痫前期患者在妊娠早期和中期的s-Met血清水平显著更低（P < 0.0001）。s-Met在妊娠早期和中期对早期子痫前期的敏感性和特异性分别为（83%，94%）和（77%，94%），对重度子痫前期的敏感性和特异性分别为（88%，92%）和（86%，98%）。结论。基于我们的研究结果，s-Met血清水平可作为子痫前期早期检测的预测因素。需要进一步研究来证实s-Met在子痫前期中的功能和治疗价值。
