Clark D E, Salvig J D, Smith S K, Charnock-Jones D S
Department of Obstetrics and Gynaecology, University of Cambridge, Rosie Hospital, UK.
Placenta. 1998 Nov;19(8):671-3. doi: 10.1016/s0143-4004(98)90029-7.
Hepatocyte growth factor (HGF), also known as scatter factor, binds the c-met receptor. It has been shown to be involved in mesenchyme-epithelial interactions. HGF is produced by the villous mesenchyme of the placenta throughout pregnancy and its receptor located on the villous cytotrophoblast cells. In this study the levels of HGF were measured in consecutive samples of plasma taken from pregnant women. Normal pregnancies were compared with intrauterine growth restricted (IUGR) pregnancies (below the third centile). In both groups, the levels of HGF were found to increase significantly as pregnancy progressed and then fall post partum. There was a considerable amount of variation found between individual women but no significant difference (P=0.65) between the normal and IUGR pregnancies.
肝细胞生长因子（HGF），也被称为分散因子，可与c-met受体结合。研究表明，它参与间充质-上皮相互作用。在整个孕期，胎盘的绒毛间充质会产生HGF，其受体位于绒毛细胞滋养层细胞上。在本研究中，对从孕妇采集的连续血浆样本中的HGF水平进行了测量。将正常妊娠与宫内生长受限（IUGR，低于第三百分位数）妊娠进行了比较。在两组中，均发现HGF水平随着妊娠进展而显著升高，产后则下降。个体女性之间存在相当大的差异，但正常妊娠和IUGR妊娠之间无显著差异（P=0.65）。
