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Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, 5th Floor, Franklin-Wilkins Building, Waterloo Campus, 150 Stamford Street, London SE1 9NH, UK.
ISRN Pharmacol. 2013 Jul 30;2013:910743. doi: 10.1155/2013/910743. eCollection 2013.
Heparin has been widely used as an anticoagulant for more than 80 years. However, there is now considerable evidence that heparin also possesses anti-inflammatory activity, both experimentally and clinically. Importantly in many instances, the anti-inflammatory actions of heparin are independent of anticoagulant activity raising the possibility of developing novel drugs based on heparin that retain the anti-inflammatory activity. Heparin exhibits anti-inflammatory activities via a variety of mechanisms including neutralization of cationic mediators, inhibition of adhesion molecules, and the inhibition of heparanase, all involved in leukocyte recruitment into tissues. It is anticipated that furthering our understanding of the anti-inflammatory actions of heparin will lead to the development of novel anti-inflammatory drugs for a variety of clinical indications.
八十多年来，肝素一直被广泛用作抗凝剂。然而，目前有大量证据表明，肝素在实验和临床中均具有抗炎活性。重要的是，在许多情况下，肝素的抗炎作用独立于抗凝活性，这增加了开发基于肝素且保留抗炎活性的新型药物的可能性。肝素通过多种机制发挥抗炎活性，包括中和阳离子介质、抑制黏附分子以及抑制乙酰肝素酶，所有这些机制都与白细胞募集到组织中有关。预计进一步了解肝素的抗炎作用将有助于开发用于多种临床适应症的新型抗炎药物。
