Department of Mathematics, Shanghai University, Shanghai 200444, China.
Biomed Res Int. 2013;2013:285063. doi: 10.1155/2013/285063. Epub 2013 Jun 26.
As a class of small noncoding RNAs, microRNAs (miRNAs) regulate stability or translation of mRNA transcripts. Some reports bring new insights into possible roles of microRNAs in modulating cell cycle. In this paper, we focus on the mechanism and effectiveness of microRNA-mediated regulation in the cell cycle. We first describe two specific regulatory circuits that incorporate base-pairing microRNAs and show their fine-tuning roles in the modulation of periodic behavior. Furthermore, we analyze the effects of miR369-3 on the modulation of the cell cycle, confirming that miR369-3 plays a role in shortening the period of the cell cycle. These results are consistent with experimental observations.
作为一类小的非编码 RNA，microRNAs（miRNAs）调节 mRNA 转录本的稳定性或翻译。一些报告为 microRNAs 在调节细胞周期中的可能作用带来了新的见解。在本文中，我们专注于 microRNA 介导的调节在细胞周期中的机制和效果。我们首先描述了两个包含碱基配对 microRNAs 的特定调节回路，并展示了它们在调节周期性行为中的微调作用。此外，我们分析了 miR369-3 对细胞周期调节的影响，证实了 miR369-3 在缩短细胞周期周期方面发挥作用。这些结果与实验观察一致。
