Tokarski Sławomir, Rutkowski Maciej, Mejer Anna, Godala Małgorzata, Kowalski Jan
Oddzial Grźllicy i Choó6b łluc, kierownik: lek. E. Schwarz; Uniwersytet Medyczny w Łtodz.
Pol Merkur Lekarski. 2013 Jul;35(205):18-21.
Lung cancer is one of the most common cancer types and it usually takes the form of non-small cell lung cancer (NSCLC). ROS take part in the process of carcinogenesis. What more, chemotherapy used in cancer treatment augments their production, leading to the weakening of the antioxidative barrier. As a result in cancer patients undergoing chemotherapy the reduction-oxidation processes are imbalanced. Vitamins A, C and E form an important part of the nonenzymatic antioxidative barrier in humans. THE AIM OF THE STUDY was an assessment of concentrations of A, C and E vitamins in the plasma of patients with NSCLC before and after chemotherapy
25 first-line chemotherapy patients with inoperable NSCLC have undergone examination, including 20 men and 5 women aged between 50-75 years (average age 62.6 +/- 6.1 years). 24 healthy individuals including 18 men and 6 women aged between 49-71 years (average age 59.5 +/- 6.6 years) formed a control group. In cancer patients the concentration of vitamins A, C and E was assessed by spectrophotometry using T60V spectrophotometer (PG Instruments) before and after first-line chemotherapy, while in control group it was assessed only once.
The concentration of A, C and E vitamins in plasma of NSCLC patients was lower (p < 0.05) than in the control group. After 6 weeks of chemotherapy another significant drop in vitamin concentrations in NSCLC patients was observed (p < 0.05) and was biggest for vitamin C (39.1%).
Lowering of A, C and E vitamins concentrations in the plasma of NSCLCpatients suggests a weakening of antioxidative barrier. Chemotherapy leads to further fall in the concentration of those vitamins in patients' plasma.
肺癌是最常见的癌症类型之一，通常表现为非小细胞肺癌（NSCLC）。活性氧（ROS）参与致癌过程。此外，癌症治疗中使用的化疗会增加其产生，导致抗氧化屏障减弱。因此，接受化疗的癌症患者体内的氧化还原过程失衡。维生素A、C和E是人体非酶抗氧化屏障的重要组成部分。本研究的目的是评估非小细胞肺癌患者化疗前后血浆中维生素A、C和E的浓度。
25例无法手术的非小细胞肺癌一线化疗患者接受了检查，其中包括20名男性和5名女性，年龄在50 - 75岁之间（平均年龄62.6±6.1岁）。24名健康个体，包括18名男性和6名女性，年龄在49 - 71岁之间（平均年龄59.5±6.6岁），组成对照组。在癌症患者中，使用T60V分光光度计（PG仪器）通过分光光度法在一线化疗前后评估维生素A、C和E的浓度，而在对照组中仅评估一次。
非小细胞肺癌患者血浆中维生素A、C和E的浓度低于对照组（p < 0.05）。化疗6周后，非小细胞肺癌患者的维生素浓度再次显著下降（p < 0.05），其中维生素C下降幅度最大（39.1%）。
非小细胞肺癌患者血浆中维生素A、C和E浓度降低表明抗氧化屏障减弱。化疗导致患者血浆中这些维生素的浓度进一步下降。
