Godala Małgorzata, Materek-Kuśmierkiewicz Izabela, Moczulski Dariusz, Rutkowski Maciej, Szatko Franciszek, Gaszyńska Ewelina, Kowalski Jan
Pol Merkur Lekarski. 2014 May;36(215):320-3.
Metabolic syndrome (MS) is a coexistence of metabolic risk factors affecting development of cardiovascular diseases. In the pathogenesis of MS there participate reactive oxygen species which are excessively produced in such elements of MS as hyperglycemia, insulin resistance and obesity. Vitamins A, C and E are an important part of the non-enzymatic antioxidative barrier in humans. The aim of the study was to estimate plasma vitamin A, C and E levels in patients with symptoms of MS.
The study included 68 patients with symptoms of MS according to International Diabetes Federation criteria (2005), 37 men and 31 women, aged 34-65 years (mean age 57, 76 +/- 8, 29 years). The control group consisted of 24 healthy individuals without MS, 18 men and 6 women, aged 49-67 (mean age 58, 5 +/- 5, 6 years). Plasma vitamin A, C and E levels were estimated in patients and the control group with spectrophotometry using T60V spectrophotometer (PG Instruments).
The plasma vitamin A, C and E levels were significantly lower (p < 0.05) in MS patients than in the healthy individuals without symptoms of MS. The most significant differences in the level of antioxidative vitamins in both groups were related to vitamin C and vitamin E.
The decreased level of vitamins A, C and E points to the weakening of antioxidative barrier in patients with MS.
代谢综合征（MS）是多种影响心血管疾病发展的代谢危险因素并存的情况。在MS的发病机制中，活性氧物质参与其中，这些物质在MS的高血糖、胰岛素抵抗和肥胖等因素中过度产生。维生素A、C和E是人体非酶抗氧化屏障的重要组成部分。本研究的目的是评估有MS症状患者的血浆维生素A、C和E水平。
本研究纳入了68例符合国际糖尿病联盟标准（2005年）的有MS症状的患者，其中37例男性和31例女性，年龄在34 - 65岁之间（平均年龄57.76±8.29岁）。对照组由24名无MS的健康个体组成，其中18例男性和6例女性，年龄在49 - 67岁之间（平均年龄58.5±5.6岁）。使用T60V分光光度计（PG仪器公司）通过分光光度法评估患者和对照组的血浆维生素A、C和E水平。
MS患者的血浆维生素A、C和E水平显著低于无MS症状的健康个体（p < 0.05）。两组抗氧化维生素水平的最显著差异与维生素C和维生素E有关。
维生素A、C和E水平降低表明MS患者的抗氧化屏障减弱。
