1 Department of Digestive Surgery, St. Maria Hospital , Terni, Italy .
Diabetes Technol Ther. 2013 Dec;15(12):1004-9. doi: 10.1089/dia.2013.0162. Epub 2013 Aug 28.
Obesity and its correlation with other pathological conditions determine the onset of the metabolic syndrome, which exposes the patient to a higher risk of major cardiovascular complications. Laparoscopic sleeve gastrectomy (LSG) is a bariatric surgical procedure that appears to influence both the reduction of fat mass and the action of some gastrointestinal hormones.
Between January 2011 and July 2013, 23 patients with morbid obesity underwent LSG and follow-up. In the evaluation of patients, the criteria for metabolic syndrome given by the International Diabetes Federation were followed. A multidisciplinary team of experts evaluated patients before surgery and in subsequent scheduled postoperative visits at 7, 30, 60, and 90 days and 4, 5, 6, 9, and 12 months. Anthropometric and metabolic parameters were analyzed.
The mean excess weight loss was 8.57±3.02%, 17.65±6.40%, 25.47±7.90%, 33.76±9.27%, 41.83±10.71%, 46.02±13.90%, 52.60±14.05%, 58.48±16.07%, and 62.59±21.29% at 7, 30, 60, and 90 days and 4, 5, 6, 9, and 12 months, respectively. In the same observational period there was an excellent improvement of metabolic indices. None of the patients previously taking prescribed hypoglycemic drugs restarted therapy. Mean fasting plasma glucose significantly decreased compared with the preoperative values. Blood pressure had a statistically significant improvement. Modification in the lipid profile was more variable. During the period of observation 22 of 23 patients reported in this study did not fit the criteria for metabolic syndrome.
Morbid obesity and related diseases may benefit from a surgical approach in selected patients. Randomized controlled trials are needed to evaluate the role of LSG.
肥胖及其与其他病理状况的相关性决定了代谢综合征的发生，这使患者面临更高的主要心血管并发症风险。腹腔镜袖状胃切除术（LSG）是一种减肥手术，它似乎影响脂肪量的减少和一些胃肠激素的作用。
2011 年 1 月至 2013 年 7 月，23 例病态肥胖患者接受 LSG 及随访。在患者评估中，遵循国际糖尿病联合会给出的代谢综合征标准。一个多学科专家团队在术前和随后的术后 7、30、60 和 90 天以及 4、5、6、9 和 12 个月进行了定期检查。分析了人体测量和代谢参数。
体重过重减轻的平均值分别为 7、30、60 和 90 天以及 4、5、6、9 和 12 个月时的 8.57±3.02%、17.65±6.40%、25.47±7.90%、33.76±9.27%、41.83±10.71%、46.02±13.90%、52.60±14.05%、58.48±16.07%和 62.59±21.29%。在同一观察期内，代谢指数有了极好的改善。没有以前服用规定降糖药物的患者重新开始治疗。空腹血浆葡萄糖与术前值相比显著降低。血压有统计学显著改善。血脂谱的变化更为多变。在观察期间，23 例患者中有 22 例不符合代谢综合征的标准。
病态肥胖及其相关疾病可能受益于选择性患者的手术治疗。需要随机对照试验来评估 LSG 的作用。
