Department of Neurology, Lillebaelt Hospital , Vejle , Denmark.
Amyotroph Lateral Scler Frontotemporal Degener. 2013 Dec;14(7-8):516-20. doi: 10.3109/21678421.2013.830312. Epub 2013 Aug 28.
Botulinum neurotoxin (BoNT) is a second-line treatment of sialorrhoea in ALS (amyotrophic lateral sclerosis) patients. This article is a review of the published literature concerning safety and administration of this treatment to ALS patients. A PubMed search was performed. All original publications on BoNT treatment of sialorrhoea in ALS patients were included in the review. Only a few adverse events were observed concerning treatment with BoNT. The studies performed to date have applied different treatment strategies with different dosages. In conclusion, BoNT treatment for sialorrhoea in ALS patients is safe with few adverse effects. The authors advocate for the implementation of a personalized treatment strategy. Special precautions must be taken when patients do not have the assistance of a ventilator and a feeding tube.
肉毒杆菌神经毒素（BoNT）是 ALS（肌萎缩侧索硬化症）患者流涎的二线治疗药物。本文综述了已发表的关于 BoNT 治疗 ALS 患者安全性和管理的文献。进行了 PubMed 检索。本综述纳入了所有关于 BoNT 治疗 ALS 患者流涎的原始出版物。仅观察到少数与 BoNT 治疗相关的不良事件。迄今为止进行的研究采用了不同剂量的不同治疗策略。总之，BoNT 治疗 ALS 患者流涎是安全的，不良事件很少。作者主张实施个性化治疗策略。当患者没有呼吸机和饲管的辅助时，必须采取特殊的预防措施。
