Massioui F E, Lille F, Lesevre N, Hazemann P, Garnier R, Dally S
Hopital de la Salpetriere, Paris.
J Toxicol Clin Toxicol. 1990;28(2):203-19. doi: 10.3109/15563659008993493.
To obtain objective measures of possible impairment due to organic solvents, auditory, visual and somatosensory evoked potentials and cognitive event related potentials were recorded in a group of 13 workers occupationally exposed to a mixture of various solvents. The patients were compared to healthy subjects and to chronic alcoholics seen during post-alcohol withdrawal. Auditory and visual evoked potentials were almost normal but somatosensory evoked potentials showed a slight decrease of peripheral conduction velocities and an increase of central conduction times more marked in the solvent exposed workers who were also alcoholics. The late "cognitive" components reflecting attention processes (N2 and P3) were normal. Solvent-exposed workers and alcoholics were both characterized by some difficulty in modulating their attentional resources according to task demands, as reflected by a tendency to responses (N1, N2 and P3) of similar amplitudes whether the stimulus was or was not the target. These findings support the presence, in solvent exposed workers, of minor dysfunction of the nervous system at both peripheral and cortical levels potentiated by alcohol as well as of mild cognitive impairments concerning attention processes.
为了获得有机溶剂可能造成损害的客观指标，我们对13名职业性接触多种溶剂混合物的工人进行了听觉、视觉和体感诱发电位以及认知事件相关电位的记录。将这些患者与健康受试者以及戒酒期的慢性酒精中毒者进行了比较。听觉和视觉诱发电位基本正常，但体感诱发电位显示外周传导速度略有下降，中枢传导时间增加，在同时也是酗酒者的溶剂接触工人中更为明显。反映注意力过程的晚期“认知”成分（N2和P3）正常。溶剂接触工人和酗酒者都表现出根据任务需求调节注意力资源存在一定困难，这表现为无论刺激是否为目标，反应（N1、N2和P3）幅度相似的趋势。这些发现支持在溶剂接触工人中存在外周和皮质水平的轻度神经系统功能障碍，酒精会使其加重，以及存在与注意力过程有关的轻度认知障碍。
