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[食管癌的分子生物学综述]

[Molecular biological review of esophageal cancer].

作者信息

Yokobori Takehiko, Kuwano Hiroyuki

机构信息

Department of General Surgical Science, Gunma University, Maebashi, Japan.

出版信息

Kyobu Geka. 2013 Jan;66(1):73-84.

PMID:23985408
Abstract

Esophageal squamous cell carcinoma accounts for most esophageal cancers in East Asia. Esophageal adenocarcinoma arises from Barrett's esophagus. However, patients with advanced disease remain poor prognosis. Therefore, it is needed to clarify the carcinogenic mechanism and cancer metastatic process in esophageal cancer. Here, we described the recent research approaches of microarray and next generation sequence in esophageal squamous cell carcinoma and esophageal adenocarcinoma.

摘要

食管鳞状细胞癌占东亚地区大多数食管癌病例。食管腺癌起源于巴雷特食管。然而,晚期疾病患者的预后仍然很差。因此,有必要阐明食管癌的致癌机制和癌症转移过程。在此,我们描述了食管鳞状细胞癌和食管腺癌中微阵列和下一代测序的最新研究方法。

相似文献

1
[Molecular biological review of esophageal cancer].[食管癌的分子生物学综述]
Kyobu Geka. 2013 Jan;66(1):73-84.
2
The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma.正常鳞状食管上皮的分子特征可识别场效应的存在,并能区分巴雷特食管患者和巴雷特相关腺癌患者。
Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2113-7. doi: 10.1158/1055-9965.EPI-05-0014.
3
Oncogene activation in esophageal cancer.食管癌中的癌基因激活
J Thorac Cardiovasc Surg. 1991 Nov;102(5):707-9.
4
p53 gene mutations in Barrett's epithelium and esophageal cancer.巴雷特食管上皮和食管癌中的p53基因突变
Cancer Res. 1991 Aug 15;51(16):4495-9.
5
Microsatellite instability occurs frequently and in both diploid and aneuploid cell populations of Barrett's-associated esophageal adenocarcinomas.微卫星不稳定性在巴雷特食管腺癌的二倍体和非整倍体细胞群体中均频繁发生。
Cancer Res. 1994 Jul 1;54(13):3379-82.
6
Frequent methylation of eyes absent 4 gene in Barrett's esophagus and esophageal adenocarcinoma.巴雷特食管和食管腺癌中无眼4基因的频繁甲基化。
Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):830-4. doi: 10.1158/1055-9965.EPI-04-0506.
7
Dedifferentiation precedes invasion in the progression from Barrett's metaplasia to esophageal adenocarcinoma.在从巴雷特化生进展为食管腺癌的过程中,去分化先于侵袭发生。
Clin Cancer Res. 2005 Apr 1;11(7):2478-85. doi: 10.1158/1078-0432.CCR-04-1280.
8
[Profile of p53 mutations and abnormal expression of P53 protein in 2 forms of esophageal cancer].[两种食管癌中p53基因突变及P53蛋白异常表达情况分析]
Gastroenterol Clin Biol. 1996;20(5):430-7.
9
The prognostic and chemotherapeutic value of miR-296 in esophageal squamous cell carcinoma.miR-296 在食管鳞癌中的预后和化疗价值。
Ann Surg. 2010 Jun;251(6):1056-63. doi: 10.1097/SLA.0b013e3181dd4ea9.
10
Polymorphic expression of the glutathione S-transferase P1 gene and its susceptibility to Barrett's esophagus and esophageal carcinoma.谷胱甘肽S-转移酶P1基因的多态性表达及其与巴雷特食管和食管癌的易感性
Cancer Res. 1999 Feb 1;59(3):586-9.

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The expression of and its inhibitory effect on cell biological behavior in esophageal squamous cell carcinoma.其在食管鳞状细胞癌中的表达及其对细胞生物学行为的抑制作用。
Onco Targets Ther. 2017 Feb 27;10:1217-1226. doi: 10.2147/OTT.S125742. eCollection 2017.
2
Evaluation of the 7(th) edition of the UICC-AJCC tumor, node, metastasis classification for esophageal cancer in a Chinese cohort.中国队列中UICC-AJCC食管癌肿瘤、淋巴结、转移分类第7版的评估。
J Thorac Dis. 2016 Jul;8(7):1672-80. doi: 10.21037/jtd.2016.06.24.
3
Expression patterns of three regulation enzymes in glycolysis in esophageal squamous cell carcinoma: association with survival.
食管鳞状细胞癌糖酵解中三种调节酶的表达模式:与生存的关联
Med Oncol. 2014 Sep;31(9):118. doi: 10.1007/s12032-014-0118-1. Epub 2014 Jul 27.