Interdisciplinary Biotechnology Unit, Aligarh Muslim University , Aligarh , India.
Front Immunol. 2013 Aug 27;4:254. doi: 10.3389/fimmu.2013.00254. eCollection 2013.
Post pathogen invasion, migration of effector T-cell subsets to specific tissue locations is of prime importance for generation of robust immune response. Effector T cells are imprinted with distinct "homing codes" (adhesion molecules and chemokine receptors) during activation which regulate their targeted trafficking to specific tissues. Internal cues in the lymph node microenvironment along with external stimuli from food (vitamin A) and sunlight (vitamin D3) prime dendritic cells, imprinting them to play centre stage in the induction of tissue tropism in effector T cells. B cells as well, in a manner similar to effector T cells, exhibit tissue-tropic migration. In this review, we have focused on the factors regulating the generation and migration of effector T cells to various tissues along with giving an overview of tissue tropism in B cells.
病原体入侵后，效应 T 细胞亚群向特定组织位置的迁移对于产生强大的免疫反应至关重要。效应 T 细胞在激活过程中被赋予独特的“归巢码”（黏附分子和趋化因子受体），调节它们靶向特定组织的迁移。淋巴结微环境中的内部线索以及来自食物（维生素 A）和阳光（维生素 D3）的外部刺激使树突状细胞成熟，使它们在诱导效应 T 细胞组织嗜性中发挥核心作用。B 细胞也以类似于效应 T 细胞的方式表现出组织嗜性迁移。在这篇综述中，我们重点介绍了调节效应 T 细胞向各种组织生成和迁移的因素，并概述了 B 细胞的组织嗜性。
