Andersen Stig, Jakobsen Anna, Rex Hanne Lynge, Lyngaard Folmer, Kleist Inge-Lise, Kern Peder, Laurberg Peter
Arctic Health Research Centre, Aalborg University Hospital, Aalborg, Denmark.
Int J Circumpolar Health. 2013 Aug 5;72. doi: 10.3402/ijch.v72i0.21225. eCollection 2013.
Vitamin D status influences skeletal health, the risk of falls and fractures, and muscle health, and it has been associated with inflammatory, infectious, cardiovascular and metabolic disorders in addition to some cancers. Prevailing intracellular infections such as tuberculosis are speculated to relate to vitamin D status. The vitamin D sources are dietary and dermal, the latter depending on UVB radiation exposure from the sun. Life in the Arctic influences vitamin D status because of dietary peculiarities, the polar night, waning of the ozone layer and maybe ethnic differences between Inuit and non-Inuit.
Data on vitamin D status as estimated by plasma 25OHD in Inuit and non-Inuit in Greenland are reviewed.
Decreasing intake of vitamin D-rich local food items associated with decreasing plasma 25OHD levels and insufficient vitamin D status is seen with low intake of traditional Inuit foods. Plasma 25OHD levels increase markedly during spring and summer in parallel with the high influx of sunlight while plasma 25OHD is not influenced by obesity in Greenland Inuit and no clear-cut association is seen between plasma 25OHD and the risk of tuberculosis.
The frequency of vitamin D deficiency in populations in Greenland rises with the dietary transition and diseases related to low vitamin D status should be monitored.
维生素D状况影响骨骼健康、跌倒和骨折风险以及肌肉健康，此外还与炎症、感染、心血管和代谢紊乱以及某些癌症有关。据推测，诸如结核病等常见的细胞内感染与维生素D状况有关。维生素D的来源包括饮食和皮肤合成，后者取决于阳光中的紫外线B辐射暴露。由于饮食特点、极夜现象、臭氧层变薄以及因纽特人和非因纽特人之间可能存在的种族差异，北极地区的生活影响维生素D状况。
回顾了格陵兰因纽特人和非因纽特人血浆25羟维生素D（25OHD）估计的维生素D状况数据。
随着富含维生素D的当地食物摄入量减少，血浆25OHD水平下降，因纽特人传统食物摄入量低时可见维生素D状况不足。在春季和夏季，随着大量阳光照射，血浆25OHD水平显著升高，而格陵兰因纽特人的血浆25OHD不受肥胖影响，且血浆25OHD与结核病风险之间未发现明确关联。
随着饮食转变，格陵兰人群中维生素D缺乏的频率上升，应监测与低维生素D状况相关的疾病。
