Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 162-1 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea.
Nanomedicine (Lond). 2013 Sep;8(9):1529-48. doi: 10.2217/nnm.13.131.
Since the pioneering research of Bangham et al. in 1965, liposomes have attracted a large amount of interest as potential carriers of various bioactive molecules for clinical applications. However, scaling-up conventional methods of liposome preparation has been proven to be challenging. Compared with conventional methods, processes that use supercritical fluid (SCF)-CO2 require a reduced amount of organic solvent, are relatively fast and simple to perform, and yield stable and more uniform liposomes. A number of studies have demonstrated that SCF-CO2 methods might be suitable for industrial-scale manufacturing of liposomes. In this review there are two topics being discussed. We provide an overview of liposomal drug products and aim to describe the physicochemical properties of liposomes prepared using various SCF methods. We review all of the available literature on SCF-CO2-based liposomes and focus on the future applications of these innovative technologies in industrial-scale liposome preparation.
自 1965 年 Bangham 等人的开创性研究以来，脂质体作为各种生物活性分子的潜在载体，引起了人们的极大兴趣，可用于临床应用。然而，已经证明扩大脂质体制备的常规方法具有挑战性。与常规方法相比，使用超临界流体（SCF）-CO2 的工艺需要较少的有机溶剂，操作相对较快且简单，并能产生稳定且更均匀的脂质体。许多研究表明，SCF-CO2 方法可能适用于脂质体的工业规模生产。在这篇综述中，讨论了两个主题。我们概述了脂质体药物产品，并旨在描述使用各种 SCF 方法制备的脂质体的物理化学性质。我们回顾了所有关于基于 SCF-CO2 的脂质体的可用文献，并重点介绍了这些创新技术在工业规模脂质体制备中的未来应用。
