聚（碘海醇）纳米颗粒作为体内 X 射线计算机断层成像的对比剂。
Poly(iohexol) nanoparticles as contrast agents for in vivo X-ray computed tomography imaging.
机构信息
Department of Materials Science and Engineering, §Department of Veterinary Clinical Medicine, and ⊥Department of Bioengineering, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
出版信息
J Am Chem Soc. 2013 Sep 18;135(37):13620-3. doi: 10.1021/ja405196f. Epub 2013 Sep 4.
Abstract
Biocompatible poly(iohexol) nanoparticles, prepared through cross-linking of iohexol and hexamethylene diisocyanate followed by coprecipitation of the resulting cross-linked polymer with mPEG-polylactide, were utilized as contrast agents for in vivo X-ray computed tomography (CT) imaging. Compared to conventional small-molecule contrast agents, poly(iohexol) nanoparticles exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, which makes it possible to acquire CT images with improved diagnosis accuracy over a broad time frame without multiple administrations.
摘要
通过将碘海醇与六亚甲基二异氰酸酯交联，然后用聚乙二醇-聚乳酸共沉淀交联聚合物，制备出生物相容性的聚（碘海醇）纳米粒子，用作体内 X 射线计算机断层扫描（CT）成像的造影剂。与传统的小分子造影剂相比，聚（碘海醇）纳米粒子在肿瘤床内的保留时间显著延长，注射后 4 小时的 CT 对比增强 36 倍，这使得在无需多次给药的情况下，可以在更广泛的时间范围内获得具有更高诊断准确性的 CT 图像。
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