重复静脉注射碘海醇对健康比格犬肾功能的影响——初步报告。
The effects of repeated intravenous iohexol administration on renal function in healthy beagles--a preliminary report.
机构信息
Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, Republic of South Africa.
出版信息
Acta Vet Scand. 2012 Aug 14;54(1):47. doi: 10.1186/1751-0147-54-47.
BACKGROUND
Contrast induced nephrotoxicity (CIN) is a well described syndrome in humans undergoing contrast medium examinations. To date CIN has received minimal attention in the veterinary literature despite increasing use of contrast medium examinations in computed tomographic studies.
METHODS
This prospective study evaluated the effect of 1290 mg/kg iohexol given intravenously to 5 normal beagle dogs in a divided dose at an interval of 6-8 weeks. Renal function was evaluated by means of scintigraphically determined glomerular filtration rate (GFR) and a variety of laboratory assays.
RESULTS
Only GFR showed a significant decrease (17%) after the second injection but not to a clinically or pathologically significant level.
CONCLUSIONS
No clinically significant effect of repeated contrast medium administration was determined in this limited study. However in dogs with reduced renal function the risk of CIN is likely to increase dramatically post contrast administration.
背景
在接受造影剂检查的人群中，对比剂诱导的肾病（CIN）是一种已被充分描述的综合征。尽管在计算机断层扫描研究中越来越多地使用造影剂检查，但迄今为止，兽医文献中对 CIN 的关注甚少。
方法
本前瞻性研究评估了将 1290mg/kg 碘海醇静脉内分剂量给予 5 只正常比格犬，间隔 6-8 周的效果。通过闪烁照相法确定的肾小球滤过率（GFR）和各种实验室检测来评估肾功能。
结果
只有第二次注射后 GFR 显著下降（17%），但未达到临床或病理显著水平。
结论
在这项有限的研究中，未确定重复造影剂给药有临床意义的影响。然而，在肾功能降低的犬中，造影后 CIN 的风险可能会显著增加。
Zotero 插件