Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base , Dayton, Ohio 45433.
Biomacromolecules. 2013 Oct 14;14(10):3509-14. doi: 10.1021/bm4008452. Epub 2013 Sep 17.
Derived from Bombyx mori cocoons, regenerated silk fibroin (RSF) exhibits excellent biocompatibility, high toughness, and tailorable biodegradability. Additionally, RSF materials are flexible, optically clear, easily patterned with nanoscale features, and may be doped with a variety bioactive species. This unique combination of properties has led to increased interest in the use of RSF in sustainable and biocompatible electronic devices. In order to explore the applicability of this biopolymer to the development of future bioelectronics, the dielectric breakdown strength (Ebd) of RSF thin films was quantified as a function of protein conformation. The application of processing conditions that increased β-sheet content (as determined by FTIR analysis) and produced films in the silk II structure resulted in RSF materials with improved Ebd with values reaching up to 400 V/μm.
从桑蚕茧中提取的再生丝素纤维（RSF）具有优异的生物相容性、高韧性和可定制的生物降解性。此外，RSF 材料具有柔韧性、光学透明性、易于纳米级特征图案化的特点，并且可以掺杂多种生物活性物质。这种独特的性能组合使得人们对将 RSF 应用于可持续和生物相容的电子设备的兴趣日益增加。为了探索这种生物聚合物在未来生物电子学发展中的适用性，我们定量研究了 RSF 薄膜的介电击穿强度（Ebd）与蛋白质构象的关系。通过应用能够增加β-折叠含量（通过傅里叶变换红外分析确定）并使薄膜形成丝素 II 结构的处理条件，得到了介电击穿强度达到 400 V/μm 的 RSF 材料。
