The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
J Psychiatr Res. 2013 Nov;47(11):1785-90. doi: 10.1016/j.jpsychires.2013.08.002. Epub 2013 Aug 26.
Pharmacotherapy and cognitive-behavioral therapy (CBT) are widely used to treat obsessive-compulsive disorder (OCD). These treatments have helped many patients with OCD, but there still is room for improvement. Recently, a promising psychotherapy for OCD, cognitive-coping therapy (CCT), has been developed. Pharmacotherapy plus CCT (PCCT) demonstrates higher efficacy in a shorter period of time and lower relapses than pharmacotherapy or pharmacotherapy plus CBT. In this randomized controlled trial, we investigated the efficacy of CCT for OCD treatment. One hundred and forty-five OCD patients were randomly assigned into two groups: pharmacotherapy (N = 72) and PCCT (N = 73). In each group, drug-resistant (DR) and non-drug-resistant (NDR) OCD were further analyzed to examine the efficacy of CCT. Some clinical features and the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) were blindly assessed pre-treatment and post-treatment at week 1, 2, 3, 4, and 12. The Y-BOCS scores were significantly lower in PCCT than in the pharmacotherapy group at any post-treatment time-point (P < 0.001). Compared with pre-treatment, the Y-BOCS scores were significantly reduced at any time-point (P < 0.001) in PCCT group, but only at week 12 (P < 0.001) in the pharmacotherapy group. In the PCCT group, there were no differences between DR and NDR groups' Y-BOCS scores at any post-treatment time-point. The response rates and remission rates were higher in PCCT than in the pharmacotherapy group. Three variables, the number of weeks of treatment, insight, and disregarding of obsessions, were significantly correlated with the Y-BOCS score. Therefore, CCT might be a potential treatment for OCD.
药物治疗和认知行为疗法（CBT）被广泛用于治疗强迫症（OCD）。这些治疗方法已经帮助许多 OCD 患者，但仍有改进的空间。最近，一种有前途的 OCD 心理治疗方法，认知应对疗法（CCT）已经被开发出来。药物治疗加 CCT（PCCT）在更短的时间内显示出更高的疗效，并且复发率低于药物治疗或药物治疗加 CBT。在这项随机对照试验中，我们研究了 CCT 治疗 OCD 的疗效。145 名 OCD 患者被随机分为两组：药物治疗组（N=72）和 PCCT 组（N=73）。在每组中，进一步分析了药物抵抗（DR）和非药物抵抗（NDR）的 OCD，以检查 CCT 的疗效。一些临床特征和耶鲁-布朗强迫症量表（Y-BOCS）在治疗前和治疗后第 1、2、3、4 和 12 周进行了盲法评估。在任何治疗后时间点，PCCT 组的 Y-BOCS 评分均明显低于药物治疗组（P<0.001）。与治疗前相比，PCCT 组在任何时间点的 Y-BOCS 评分均显著降低（P<0.001），但药物治疗组仅在第 12 周（P<0.001）。在 PCCT 组中，DR 和 NDR 组在任何治疗后时间点的 Y-BOCS 评分均无差异。PCCT 组的反应率和缓解率高于药物治疗组。有三个变量，治疗周数、洞察力和忽视强迫，与 Y-BOCS 评分显著相关。因此，CCT 可能是 OCD 的一种潜在治疗方法。
