Klein-Goldberg Anat, Maman Shelly, Witz Isaac P
Department of Cell Research and Immunology, George S. Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Department of Cell Research and Immunology, George S. Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, 21201 MD, USA.
Cancer Lett. 2014 Sep 28;352(1):54-8. doi: 10.1016/j.canlet.2013.08.029. Epub 2013 Aug 27.
Cancer cells that disseminate to metastatic sites may progress to frank metastasis or persist as dormant micrometastasis. Significant progress has been made in defining the genetic and phenotypic cancer-cell-autonomous determinants of metastasis and in the understanding of the cross-talk between metastasizing tumor cells and the metastatic microenvironment. However several questions remain open, in particular the identity of microenvironmental factors that keep micrometastatic cells in a state of dormancy and those that promote survival, proliferation and progression of such cells. Significantly more information is available on the latter factors than on microenvironmental cells and molecules that restrain micrometastasis. This mini-review summarizes findings suggesting that: In view of the above, it is not unlikely that metastases residing in different microenvironments may require "individualized" treatment modalities.
扩散至转移部位的癌细胞可能发展为明显的转移灶，或作为休眠微转移灶持续存在。在确定转移的基因和表型癌细胞自主决定因素以及理解转移肿瘤细胞与转移微环境之间的相互作用方面已经取得了重大进展。然而，仍有几个问题尚未解决，特别是使微转移细胞处于休眠状态的微环境因素以及促进此类细胞存活、增殖和进展的因素的身份。关于后一类因素的信息明显多于抑制微转移的微环境细胞和分子。本综述总结了研究结果，表明：鉴于上述情况，位于不同微环境中的转移灶可能需要“个性化”治疗方式，这并非不可能。
