白三烯B4，一种针对病原体的先天性免疫反应的内源性刺激物。
Leukotriene B4, an endogenous stimulator of the innate immune response against pathogens.
作者信息
Le Bel Manon, Brunet Alexandre, Gosselin Jean
机构信息
Laboratory of Innate Immunology, Centre Hospitalier Universitaire de Québec, and Department of Molecular Medicine, Laval University, Quebec City, Que., Canada.
出版信息
J Innate Immun. 2014;6(2):159-68. doi: 10.1159/000353694. Epub 2013 Aug 28.
Abstract
Leukotriene B4 (LTB4) is an endogenous lipid mediator of inflammation derived from arachidonic acid by the sequential action of cytosolic phospholipase A2 and 5-lipoxygenase. This mediator was initially recognized for its involvement in the recruitment of neutrophils. However, in the last decade, LTB4 has been clearly demonstrated to play a significant role in the control of microbial infections through its ability to activate host innate defenses. In this review, we will focus on the modulator effects of LTB4 on the innate defenses and discuss its therapeutic potential against viral pathogens.
摘要
白三烯B4（LTB4）是一种内源性炎症脂质介质，由花生四烯酸通过胞质磷脂酶A2和5-脂氧合酶的相继作用产生。这种介质最初因其在中性粒细胞募集中的作用而被认识。然而，在过去十年中，LTB4已被明确证明通过激活宿主先天防御的能力在控制微生物感染中发挥重要作用。在本综述中，我们将重点关注LTB4对先天防御的调节作用，并讨论其针对病毒病原体的治疗潜力。
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