Nakagawa K, Furusawa A, Momono S, Sasaki Y, Ujiie K
Department of Surgery, Sendai Red Cross Hospital, Japan.
Nihon Geka Gakkai Zasshi. 1990 Jun;91(6):771-3.
A 76-year-old man with congenital factor VII deficiency was admitted to our hospital for the treatment of gastric cancer. On admission, the hepaplastin test was prolonged reaching to 21% and factor VII activity was reduced to 8%. After preoperative heat-treated prothrombin complex concentrates loading test, factor VII levels had been maintained above 20% by every four-hour infusion of concentrates during operation and the first post operative day. Bleeding tendency didn't occur, but thrombosis occurred at the left femoral vein. Pre and postoperative replacement therapy is essential to the patient with congenital factor VII deficiency for the safety of operation.
一名76岁先天性因子VII缺乏症男性因胃癌入院治疗。入院时,肝促凝血酶原激酶试验延长至21%,因子VII活性降至8%。术前进行热处理凝血酶原复合物浓缩物负荷试验后,术中及术后第一天每四小时输注浓缩物,因子VII水平维持在20%以上。未出现出血倾向,但左股静脉发生血栓形成。对于先天性因子VII缺乏症患者,术前和术后的替代治疗对于手术安全至关重要。