Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Am J Nephrol. 2013;38(3):212-7. doi: 10.1159/000354312. Epub 2013 Aug 27.
Living donor kidneys have been associated with better graft and overall survival in kidney transplant recipients. Although a living kidney donation is generally considered safe in carefully selected living donors, concerns of possible adverse effects related to kidney donation remain, especially in younger and high-risk donors. In this study, we examined the changes in a panel of traditional and novel serum biomarkers linked with cardiovascular conditions in a cohort of 34 healthy living kidney donors with a mean age ± SD of 40 ± 10 years and estimated predonation glomerular filtration rate (GFR) of 86 ± 10 ml/min/1.73 m(2). At 6 months after donation, there were no significant changes in the clinical parameters including body mass index and blood pressure despite a significant decline in the mean estimated GFR to 60 ml/min/1.73 m(2). Among the panel of markers, the levels of symmetric dimethylarginine and fibroblast growth factor 23 increased significantly compared to baseline, suggesting that living kidney donation may result in changes in biomarkers that are associated with cardiovascular risk in other cohorts.
活体供肾与肾移植受者的移植物和总体存活率提高有关。尽管在经过精心挑选的活体供者中，活体肾捐献通常被认为是安全的，但人们仍然担心与肾捐献相关的可能不良影响，尤其是在年轻和高危供者中。在这项研究中，我们检查了 34 名平均年龄 ± SD 为 40 ± 10 岁且估计预捐肾肾小球滤过率（GFR）为 86 ± 10 ml/min/1.73 m2 的健康活体肾供者队列中与心血管状况相关的一系列传统和新型血清生物标志物的变化。尽管平均估计 GFR 下降至 60 ml/min/1.73 m2，但在捐赠后 6 个月时，包括体重指数和血压在内的临床参数没有明显变化。在该标志物组中，与基线相比，对称二甲基精氨酸和成纤维细胞生长因子 23 的水平显著升高，这表明活体肾捐献可能导致与其他队列中心血管风险相关的生物标志物发生变化。
